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      • Article

      Innovations in Retail Operations: Thirty Years of Lessons from Production and Operations Management

      By: Marshall Fisher and Ananth Raman
      We review papers published in Production and Operations Management (POM) during its thirty-year history that deal with retail operations issues with an empirical approach. The papers span a range of issues, from traditional ones like forecasting and inventory... View Details
      Keywords: RFID; Innovation and Invention; Technology Adoption; Operations; E-commerce; Strategy; Retail Industry
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      Fisher, Marshall, and Ananth Raman. "Innovations in Retail Operations: Thirty Years of Lessons from Production and Operations Management." Special Issue on The 30th Anniversary Issue of Production and Operations Management edited by Subodha Kumar and Christopher S. Tang. Production and Operations Management 31, no. 12 (December 1, 2022): 4452–4461.
      • 2022
      • Working Paper

      Regulatory Incentives for Innovation: The FDA's Breakthrough Therapy Designation

      By: Amitabh Chandra, Jennifer Kao, Kathleen Miller and Ariel D. Stern
      Regulators of new products confront a tradeoff between speeding a new product to market and collecting additional product quality information. The FDA’s Breakthrough Therapy Designation (BTD) provides an opportunity to understand if a regulator can use new policy to... View Details
      Keywords: Research and Development; Governing Rules, Regulations, and Reforms; Product Development
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      Chandra, Amitabh, Jennifer Kao, Kathleen Miller, and Ariel D. Stern. "Regulatory Incentives for Innovation: The FDA's Breakthrough Therapy Designation." NBER Working Paper Series, No. 30712, December 2022.
      • December 2022
      • Article

      The Contribution of Price Growth to Pharmaceutical Revenue Growth in the United States: Evidence from Medicines Sold in Retail Pharmacies

      By: Pragya Kakani, Michael Chernew and Amitabh Chandra
      Context: To what extent does pharmaceutical revenue growth depend on new medicines versus increasing prices for existing medicines? Moreover, does using list prices, as is commonly done, instead of prices net of confidential rebates offered by manufacturers, which are... View Details
      Keywords: Revenue; Price; Policy; Business Strategy; Pharmaceutical Industry
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      Kakani, Pragya, Michael Chernew, and Amitabh Chandra. "The Contribution of Price Growth to Pharmaceutical Revenue Growth in the United States: Evidence from Medicines Sold in Retail Pharmacies." Journal of Health Politics, Policy and Law 47, no. 6 (December 2022): 629–648.
      • November 2022 (Revised March 2024)
      • Case

      Replika AI: Monetizing a Chatbot

      By: Julian De Freitas and Nicole Tempest Keller
      In early 2018, Eugenia Kuyda, co-founder and CEO of San Francisco-based chatbot Replika AI, was deciding how to monetize the app she had built. Launched in 2017, Replika was a consumer AI “companion app” developed by a team of AI software engineers originally based in... View Details
      Keywords: Mental Health; Subscriber Models; TAM; Monetization Strategy; Marketing Strategy; Product Marketing; AI and Machine Learning; Applications and Software; Product Positioning; Health Disorders; Technology Industry
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      De Freitas, Julian, and Nicole Tempest Keller. "Replika AI: Monetizing a Chatbot." Harvard Business School Case 523-016, November 2022. (Revised March 2024.)
      • November 2022 (Revised April 2023)
      • Supplement

      HTC and Virtual Reality (B)

      By: Andy Wu and Matt Higgins
      In April 2023, Cher Wang, CEO and Chairwoman of HTC, reflected on her time as a leader in the virtual reality industry from her office high above Taoyuan City, Taiwan. It had been a roller coaster ride of new product introductions and unexpected challenges for HTC and... View Details
      Keywords: VR; Virtual Reality; Strategy; Metaverse; Market Entry and Exit; Competition; Technology Industry; Taiwan; China; United States
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      Wu, Andy, and Matt Higgins. "HTC and Virtual Reality (B)." Harvard Business School Supplement 723-403, November 2022. (Revised April 2023.)
      • November 2022
      • Case

      Ajax Health: A New Model for Medical Technology Innovation

      By: Regina E. Herzlinger and Ben Creo
      This case teaches key success factors for both startup and established MedTech firms. It examines how to structure a firm to maximize innovation and financial returns with organizational structures that better align the incentives for the different skill sets... View Details
      Keywords: Business Startups; Success; Innovation Strategy; Mergers and Acquisitions; Market Entry and Exit; Financial Strategy; Business Model; Partners and Partnerships; Entrepreneurship; Private Equity; Technology Industry; Medical Devices and Supplies Industry
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      Herzlinger, Regina E., and Ben Creo. "Ajax Health: A New Model for Medical Technology Innovation." Harvard Business School Case 323-043, November 2022.
      • October 25, 2022
      • Article

      Why Sharing Economic Growth with the Community Is Good Business

      By: José A. Tiburcio, Lino Miguel Dias and Robert S. Kaplan
      Subsistence dairy ranchers in Central America struggle to stay afloat during the dry season when grass is scarce. Global life sciences company Bayer has launched a program to enable them to produce their own corn silage feed. The results of this program are helping to... View Details
      Keywords: Sharing Economy; Innovation; Economic Growth; Poverty; Production; Supply Chain; Social Enterprise; Agriculture and Agribusiness Industry; Central America
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      Tiburcio, José A., Lino Miguel Dias, and Robert S. Kaplan. "Why Sharing Economic Growth with the Community Is Good Business." Harvard Business Review (website) (October 25, 2022).
      • October 2022 (Revised October 2022)
      • Case

      Lyra Health: Transforming Mental Health

      By: Rembrand Koning and Nicole Keller
      In January 2022, Lyra Health was deciding between several different alternatives to grow the business. Founded in 2015, Lyra Health, was a digital mental health platform that combined technology with human therapists and coaches to deliver high quality mental health... View Details
      Keywords: Mental Health; Health Care and Treatment; Corporate Entrepreneurship; Customer Value and Value Chain; Growth and Development Strategy; Expansion; Health Industry; Technology Industry; San Francisco
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      Koning, Rembrand, and Nicole Keller. "Lyra Health: Transforming Mental Health." Harvard Business School Case 723-365, October 2022. (Revised October 2022.)
      • October 2022
      • Supplement

      Single Earth: Science White Paper Supplement

      By: Rembrand Koning and Emer Moloney
      Science White Paper prepared by Single.Earth to give an overview of the models and solutions it has developed. View Details
      Keywords: Business Startups; Entrepreneurship; Climate Change; Environmental Sustainability; Green Technology; Natural Resources; Pollution; Analytics and Data Science; Marketing; Product Marketing; Product Launch; Product Positioning; Markets; Market Timing; Strategy; Green Technology Industry; Estonia
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      Koning, Rembrand, and Emer Moloney. "Single Earth: Science White Paper Supplement." Harvard Business School Supplement 723-389, October 2022.
      • October 2022
      • Case

      Single.Earth

      By: Rembrand Koning and Emer Moloney
      Estonian greentech company Single.Earth is launching a nature-backed token that is linked to and funds the protection of a specific plot fo land. The first landowners had been onboarded to the company's Digital Twin, a virtual representation of the planet's natural... View Details
      Keywords: Alternative Assets; Business Startups; Entrepreneurship; Climate Change; Environmental Sustainability; Green Technology; Natural Resources; Pollution; Analytics and Data Science; Marketing; Product Marketing; Product Launch; Product Positioning; Markets; Market Timing; Strategy; Green Technology Industry; Estonia
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      Koning, Rembrand, and Emer Moloney. "Single.Earth." Harvard Business School Case 723-388, October 2022.
      • October 2022
      • Case

      Afrigen Biologics: Vaccines for the Global South

      By: Debora L. Spar and Julia Comeau
      The majority of vaccines used on the continent of Africa (99%) are produced offshore. This makes African nations reliant on the West for major health care needs, a problem which was exacerbated by the COVID-19 pandemic. Afrigen Biologics (in partnership with the WHO)... View Details
      Keywords: Vaccination; Vaccine; mRNA; COVID; COVID-19; Inequity; Hub-and-spoke; Health Care and Treatment; Health Pandemics; Production; Social Issues; Business and Government Relations; South Africa; Africa
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      Spar, Debora L., and Julia Comeau. "Afrigen Biologics: Vaccines for the Global South." Harvard Business School Case 323-030, October 2022.
      • October 2022 (Revised December 2022)
      • Case

      Reimagining Enel: Enabling Sustainable Progress (A)

      By: Michael L. Tushman and Kerry Herman
      CEO Francesco Starace is considering what is next for Enel SpA, one of world's largest energy companies. From 2014 to 2022, he has wrought a dramatic transformation at Enel, restructuring the company's business units; redeploying senior talent across functions and... View Details
      Keywords: Leadership; Leadership And Change Management; Leadership Style; Leadership Succession; Renewables; Energy; Transformation; Renewable Energy; Business Divisions; Digital Transformation; Restructuring; Organizational Structure; Energy Industry; Europe; Latin America; North America; Spain; Italy
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      Tushman, Michael L., and Kerry Herman. "Reimagining Enel: Enabling Sustainable Progress (A)." Harvard Business School Case 423-001, October 2022. (Revised December 2022.)
      • October 2022 (Revised September 2024)
      • Case

      mPharma: Scaling Access to Affordable Primary Care in Africa

      By: Regina E. Herzlinger and Ben Creo
      mPharma hopes to scale up to create the largest pan-African healthcare company ever to provide much-needed primary care in retail pharmacies; a reliable, fairly priced supply of drugs; and micro-insurance for drugs. They must prioritize launching a telemedicine... View Details
      Keywords: Africa; Pharmaceutical Companies; Pharmacy Benefit Manager; Health Care; Health Care And Treatment; Health Care Costs; Health Care Delivery; Health Care Entrepreneurship; Telehealth; Health Equity; Corporate Strategy; Social Entrepreneurship; Equity; Growth and Development Strategy; Expansion; Product Launch; Customer Value and Value Chain; Social Enterprise; Multinational Firms and Management; Pharmaceutical Industry; Health Industry; Africa
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      Herzlinger, Regina E., and Ben Creo. "mPharma: Scaling Access to Affordable Primary Care in Africa." Harvard Business School Case 323-033, October 2022. (Revised September 2024.)
      • June 2022
      • Article

      A New Initiative to Track HIV Resource Allocation and Costs

      By: Ryan McBain, AK Nandakumar, Michael Ruffner, Carlyn Mann, Mai Hijazi, Susanna Baker, Linden Morrison, Kalipso Chalkidou, Shufang Zhang, Iris Semini, Fern Terris-Prestholt, Steven Forsythe, Sarah Byakika, Joshua Musinguzi and Robert S. Kaplan
      In early 2020, several global health institutions – including the Global Fund to Fight AIDS, Tuberculosis and Malaria; Joint United Nations Program on HIV/AIDS (UNAIDS); United States Agency for International Development; and Office of the Global AIDS Coordinator at... View Details
      Keywords: Activity Based Costing; HIV; Cost; Health Care; Healthcare; Health Care and Treatment; Activity Based Costing and Management; Resource Allocation; Health Industry; Africa
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      McBain, Ryan, AK Nandakumar, Michael Ruffner, Carlyn Mann, Mai Hijazi, Susanna Baker, Linden Morrison, Kalipso Chalkidou, Shufang Zhang, Iris Semini, Fern Terris-Prestholt, Steven Forsythe, Sarah Byakika, Joshua Musinguzi, and Robert S. Kaplan. "A New Initiative to Track HIV Resource Allocation and Costs." Bulletin of the World Health Organization 100, no. 6 (June 2022): 358–358A.
      • October 2022
      • Supplement

      Framebridge (B): A New Approach

      By: Rembrand Koning and Alicia Dadlani
      In 2022, after revamping operations and expanding retail stores, Framebridge founder and CEO Susan Tynan is optimistic for the future but realizes changing market dynamics. New competitors are entering the market, and margin pressures remained. This case is part two of... View Details
      Keywords: Business Startups; Business Strategy; Entrepreneurship; Operations; Market Entry and Exit; Consumer Products Industry; United States; District of Columbia; Kentucky
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      Koning, Rembrand, and Alicia Dadlani. "Framebridge (B): A New Approach." Harvard Business School Supplement 723-353, October 2022.
      • September 2022 (Revised November 2023)
      • Case

      Wordle

      By: Karen G. Mills, Christina Wallace, Ebehi Iyoha, Gabriella Elanbeck and Morgane Herculano
      After sourdough bread, countertop chive gardens, and vaccine selfies came a pandemic-era trend that everyone seemed to be in on: one daily chance to guess a five-letter word and crow about your success on social media via little green and yellow squares. From a... View Details
      Keywords: Games; Innovation; General Management; Mergers and Acquisitions; Trends; Entrepreneurship; Bids and Bidding; Consumer Behavior; Entertainment and Recreation Industry; Technology Industry
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      Mills, Karen G., Christina Wallace, Ebehi Iyoha, Gabriella Elanbeck, and Morgane Herculano. "Wordle." Harvard Business School Case 323-032, September 2022. (Revised November 2023.)
      • September 2022
      • Case

      Proactive for Her

      By: Rembrand Koning and Kairavi Dey
      Proactive for Her began amid the COVID-19 pandemic, in August 2020 as a digital platform to provide accessible, evidence-based, primary, preventive non-judgmental healthcare services for Indian women, who were often dissuaded from seeking help as premarital sex and... View Details
      Keywords: Women's Health; Healthcare; India; Start-up; Telehealth; Digital Platforms; Health Care and Treatment; Customer Focus and Relationships; Business Startups; Health Industry; Asia; South Asia; India
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      Koning, Rembrand, and Kairavi Dey. "Proactive for Her." Harvard Business School Case 723-351, September 2022.
      • August 2022 (Revised October 2023)
      • Case

      Bajaj Finance: Building an Omnipresent Financial Services Firm

      By: Das Narayandas and Rachna Tahilyani
      Bajaj Finance, India’s largest consumer finance firm with $20.9 billion of assets across 50.5 million customers, is on a journey to transform itself from a traditional firm that sells loans and other financial products through brick-and-mortar outlets to an omnipresent... View Details
      Keywords: Financial Institutions; Transformation; Financial Instruments; Customer Satisfaction; Internet and the Web; Customer Focus and Relationships; India
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      Narayandas, Das, and Rachna Tahilyani. "Bajaj Finance: Building an Omnipresent Financial Services Firm." Harvard Business School Case 523-040, August 2022. (Revised October 2023.)
      • August 2022
      • Exercise

      Joy4Home Brands: Pricing Matters

      By: Elie Ofek, Oded Koenigsberg and Marco Bertini
      Joy4Home Brands, the maker of novel houseware items, was gearing up for its launch. The company would be introducing two lines: kitchenware products and storage containers. The initial go-to-market plan called for a direct to consumer (DTC) channel strategy. While... View Details
      Keywords: DTC; Pricing Decisions; B2B; Product Marketing; Product Launch; Marketing Strategy; Business Model; Opportunities; Consumer Products Industry
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      Ofek, Elie, Oded Koenigsberg, and Marco Bertini. "Joy4Home Brands: Pricing Matters." Harvard Business School Exercise 523-709, August 2022.
      • August 2022 (Revised March 2025)
      • Case

      Wasabi Technologies (A)

      By: N. Louis Shipley and Mel Martin
      After launching a successful hot cloud storage company, Founder and CEO David Friend is ready to scale the venture rapidly. Wasabi Technologies had focused primarily on direct sales, but an opportunity to pivot to channel sales was on the horizon. The company’s major... View Details
      Keywords: Direct Sales; Channel Sales; Information Management; Sales; Product Development; Growth and Development Strategy; Business Divisions; Information Technology Industry; United States
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      Shipley, N. Louis, and Mel Martin. "Wasabi Technologies (A)." Harvard Business School Case 823-021, August 2022. (Revised March 2025.)
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