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      • 2025
      • Working Paper

      Warnings and Endorsements: Improving Human-AI Collaboration in the Presence of Outliers

      By: Matthew DosSantos DiSorbo, Kris Ferreira, Maya Balakrishnan and Jordan Tong
      Problem definition: While artificial intelligence (AI) algorithms may perform well on data that are representative of the training set (inliers), they may err when extrapolating on non-representative data (outliers). How can humans and algorithms work together to make... View Details
      Keywords: AI and Machine Learning; Decision Choices and Conditions
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      DosSantos DiSorbo, Matthew, Kris Ferreira, Maya Balakrishnan, and Jordan Tong. "Warnings and Endorsements: Improving Human-AI Collaboration in the Presence of Outliers." Working Paper, May 2025.
      • January 2024 (Revised April 2024)
      • Case

      Target Malaria: Editing Mosquitoes through Gene Drives

      By: Shikhar Ghosh and Shweta Bagai
      Target Malaria, a non-profit research consortium, is exploring the application of CRISPR-Cas9 gene editing technology to combat malaria in Sub-Saharan Africa. Its approach uses gene drives, a revolutionary tool, to suppress the population of malaria-carrying... View Details
      Keywords: Health Disorders; Technological Innovation; Nonprofit Organizations; Business Strategy; Genetics; Ethics; Governing Rules, Regulations, and Reforms; United States; United Kingdom; Burkina Faso; Africa
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      Ghosh, Shikhar, and Shweta Bagai. "Target Malaria: Editing Mosquitoes through Gene Drives." Harvard Business School Case 824-068, January 2024. (Revised April 2024.)
      • January 2024
      • Supplement

      Buurtzorg

      By: Ethan Bernstein and Tatiana Sandino
      As co-founders of home nursing company Buurtzorg, Jos de Blok and Gonnie Kronenberg prized both self-management and organizational learning. Buurtzorg’s 10,000 nurses across 950 neighborhood nursing teams in the Netherlands were empowered to manage themselves, both in... View Details
      Keywords: Organizational Design; Management Style; Business Model; Knowledge Dissemination; Learning; Organizational Culture; Health Industry; Netherlands
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      Bernstein, Ethan, and Tatiana Sandino. "Buurtzorg." Harvard Business School Multimedia/Video Supplement 424-705, January 2024.
      • 2024
      • Report

      Overcoming Barriers to Resolving Gaza and Beyond

      By: James K. Sebenius
      As of early January 2024, discussion of the Gaza war heavily focuses on its humanitarian costs, cease fire possibilities, hostage prospects, and “day after” options. Yet what longer-term strategy guides actions on these vital issues while offering a more positive... View Details
      Keywords: Negotiation; War; International Relations; Israel; Middle East
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      Sebenius, James K. "Overcoming Barriers to Resolving Gaza and Beyond." Report, Belfer Center for Science and International Affairs, January 2024.
      • January 2024 (Revised October 2024)
      • Case

      DO & CO: Crafting Luxury in the Fast Lane (A)

      By: Juan Alcácer, Esel Cekin, Michael Lee and Noah Roberson
      In July 2023, Attila Dogudan, the chairman of DO & CO, a renowned international catering firm, found himself in a deep conversation with his two sons about a potential new venture: catering for the Las Vegas Grand Prix, a significant step beyond their 31-year history... View Details
      Keywords: Decision Choices and Conditions; Health Pandemics; Opportunities; Corporate Strategy; Luxury; Food and Beverage Industry; Las Vegas
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      Alcácer, Juan, Esel Cekin, Michael Lee, and Noah Roberson. "DO & CO: Crafting Luxury in the Fast Lane (A)." Harvard Business School Case 724-416, January 2024. (Revised October 2024.)
      • January 19, 2024
      • Article

      Value-Based Health Care Can Transform the Treatment of Patients with Substance Use Disorder

      By: Robert S. Kaplan and Sarah E. Wakeman
      U.S. overdose deaths currently exceed 100,000 per year. New facilities, known as bridge clinics, are broadening access to high-quality care by offering outpatient substance use disorder (SUD) treatment with few access barriers. But many of the critical services offered... View Details
      Keywords: Health Care and Treatment; Cost; Adoption
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      Kaplan, Robert S., and Sarah E. Wakeman. "Value-Based Health Care Can Transform the Treatment of Patients with Substance Use Disorder." Health Affairs Forefront (January 19, 2024).
      • 2024
      • Working Paper

      Contributing to Growth? The Role of Open Source Software for Global Startups

      By: Nataliya Langburd Wright, Frank Nagle and Shane Greenstein
      How does participating in open source software (OSS) communities spur entrepreneurial growth? To address this question, we analyze novel data matching accounts from GitHub—the largest OSS hosting platform—to the universe of global software venture-backed firms... View Details
      Keywords: Applications and Software; Open Source Distribution; Entrepreneurship; Business Growth and Maturation; Human Capital; Valuation; Corporate Strategy
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      Wright, Nataliya Langburd, Frank Nagle, and Shane Greenstein. "Contributing to Growth? The Role of Open Source Software for Global Startups." Harvard Business School Working Paper, No. 24-040, January 2024. (Revised August 2024.)
      • January 2024 (Revised April 2024)
      • Teaching Note

      Somatus: Value-Based Kidney Care (A) & (B)

      By: Ariel D. Stern, Robert S. Huckman and Sarah Mehta
      This teaching note accompanies case no. 622-009 and 622-045 (Somatus: Value-Based Kidney Care, A and B). View Details
      Keywords: Business Startups; Disruption; Entrepreneurship; Health Care and Treatment; Health Disorders; Medical Specialties; Innovation and Invention; Disruptive Innovation; Management; Business Strategy; Value Creation; Health Industry; United States; Virginia
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      Stern, Ariel D., Robert S. Huckman, and Sarah Mehta. "Somatus: Value-Based Kidney Care (A) & (B)." Harvard Business School Teaching Note 624-013, January 2024. (Revised April 2024.)
      • January 2024
      • Background Note

      Evaluating Innovations in the Organization of Primary Care: What Type of Innovation Is It and How Well Does It Align with the Six Factors?

      By: Regina E. Herzlinger and James Wallace
      How can we evaluate if innovative health care ventures can do good—benefit society—and do well—become financially viable? This question is the topic of the first module in the Innovating in Health Care course book.

      This note and "Health Stop (A): What Type... View Details
      Keywords: Business Model; Health Care and Treatment; Collaborative Innovation and Invention; Mission and Purpose; Alignment; Health Industry
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      Herzlinger, Regina E., and James Wallace. "Evaluating Innovations in the Organization of Primary Care: What Type of Innovation Is It and How Well Does It Align with the Six Factors?" Harvard Business School Background Note 324-037, January 2024.
      • January 2024
      • Case

      Vibrant Health

      By: Henry McGee and Sarah Mehta
      This case is about nutritional supplements company Vibrant Health, among the 100 largest Black-owned businesses in the U.S. After acquiring the company from its white founder in 2007, co-owners Ted and Paige Parker significantly grew its sales. Set in September 2023,... View Details
      Keywords: Business Ventures; Race; Entrepreneurship; Nutrition; Ownership; Business Strategy; Growth and Development Strategy; Leadership; Sales; Food and Beverage Industry; Food and Beverage Industry; Eastern United States
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      McGee, Henry, and Sarah Mehta. "Vibrant Health." Harvard Business School Case 824-058, January 2024.
      • January 2024
      • Technical Note

      The ICARUS Principles: What It Takes to Tackle the World

      By: Debora L. Spar and Julia M. Comeau
      Over the course of the 20th century, most of the world’s major multinational corporations framed their mission around Milton Friedman’s famous mantra: that the sole purpose of the firm is to maximize its shareholders’ profits. Recently, however, growing numbers of... View Details
      Keywords: Purpose; Mission; Social Business; Corporate Social Responsibility and Impact; Mission and Purpose; Social Enterprise; For-Profit Firms
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      Spar, Debora L., and Julia M. Comeau. "The ICARUS Principles: What It Takes to Tackle the World." Harvard Business School Technical Note 324-055, January 2024.
      • January 2024
      • Case

      Sprouts Farmers Market

      By: Rajiv Lal, Forest L. Reinhardt and Natalie Kindred
      Sprouts Farmers Markets (Sprouts) is a Phoenix, Arizona-based chain of 400-plus natural foods stores in 23 U.S. states and $6.4 billion in sales as of 2022. In its product assortment, brand image, and store environment, Sprouts emphasizes freshness, health, innovation,... View Details
      Keywords: Business Model; Growth and Development Strategy; Brands and Branding; Strategic Planning; Sales; Business Strategy; Expansion; Product Positioning; Marketing Strategy; Competition; Retail Industry; United States; Arizona
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      Lal, Rajiv, Forest L. Reinhardt, and Natalie Kindred. "Sprouts Farmers Market." Harvard Business School Case 524-059, January 2024.
      • January 2024
      • Article

      A Cost Model for a Low Threshold Clinic Treating Opioid Use Disorder

      By: Sarah E. Wakeman, Elizabeth Powell, Syed Shehab, Grace Herman, Laura Kehoe and Robert S. Kaplan
      The US fee-for-service payment system under-reimburses clinics offering access to comprehensive treatments for opioid use disorder (OUD). The funding shortfall limits a clinic’s ability to expand and improve access, especially for socially marginalized patients with... View Details
      Keywords: Health Care and Treatment; Cost; Equality and Inequality; Health Industry
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      Wakeman, Sarah E., Elizabeth Powell, Syed Shehab, Grace Herman, Laura Kehoe, and Robert S. Kaplan. "A Cost Model for a Low Threshold Clinic Treating Opioid Use Disorder." Journal of Behavioral Health Services & Research 51, no. 1 (January 2024): 22–30.
      • January 2024
      • Article

      Cost of Exempting Sole Orphan Drugs from Medicare Negotiation

      By: Matthew Vogel, Olivia Zhao, William B. Feldman, Amitabh Chandra, Aaron S. Kesselheim and Benjamin N. Rome
      Importance: The Inflation Reduction Act (IRA) requires Medicare to negotiate prices for some high-spending drugs but exempts drugs approved solely for the treatment of a single rare disease.
      Objective: To estimate Medicare spending and global... View Details
      Keywords: Health Care and Treatment; Insurance; Price; Health Industry
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      Vogel, Matthew, Olivia Zhao, William B. Feldman, Amitabh Chandra, Aaron S. Kesselheim, and Benjamin N. Rome. "Cost of Exempting Sole Orphan Drugs from Medicare Negotiation." JAMA Internal Medicine 184, no. 1 (January 2024): 63–69.
      • January 2024
      • Article

      Population Interference in Panel Experiments

      By: Kevin Wu Han, Guillaume Basse and Iavor Bojinov
      The phenomenon of population interference, where a treatment assigned to one experimental unit affects another experimental unit’s outcome, has received considerable attention in standard randomized experiments. The complications produced by population interference in... View Details
      Keywords: Outcome or Result; Research; Situation or Environment
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      Han, Kevin Wu, Guillaume Basse, and Iavor Bojinov. "Population Interference in Panel Experiments." Journal of Econometrics 238, no. 1 (January 2024).
      • January–February 2024
      • Article

      Shared Service Delivery Can Increase Client Engagement: A Study of Shared Medical Appointments

      By: Ryan W. Buell, Kamalini Ramdas, Nazlı Sönmez, Kavitha Srinivasan and Rengaraj Venkatesh
      Problem Definition: Clients and service providers alike often consider one-on-one service delivery to be ideal, assuming – perhaps unquestioningly – that devoting individualized attention best improves client outcomes. In contrast, in shared service delivery, clients... View Details
      Keywords: Health Care and Treatment; Customer Satisfaction; Outcome or Result; Performance Improvement
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      Buell, Ryan W., Kamalini Ramdas, Nazlı Sönmez, Kavitha Srinivasan, and Rengaraj Venkatesh. "Shared Service Delivery Can Increase Client Engagement: A Study of Shared Medical Appointments." Manufacturing & Service Operations Management 26, no. 1 (January–February 2024): 154–166.
      • January 2024
      • Article

      Subset Scanning for Multi-Trait Analysis Using GWAS Summary Statistics

      By: Rui Cao, Evan Olawsky, Edward McFowland III, Erin Marcotte, Logan Spector and Tianzhong Yang
      Multi-trait analysis has been shown to have greater statistical power than single-trait analysis. Most of the existing multi-trait analysis methods only work with a limited number of traits and usually prioritize high statistical power over identifying relevant traits,... View Details
      Keywords: Mathematical Methods; Health Disorders
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      Cao, Rui, Evan Olawsky, Edward McFowland III, Erin Marcotte, Logan Spector, and Tianzhong Yang. "Subset Scanning for Multi-Trait Analysis Using GWAS Summary Statistics." Bioinformatics 40, no. 1 (January 2024).
      • 2024
      • Report

      The Eco-Digital EraTM: The Dual Transition to a Sustainable and Digital Economy

      By: Suraj Srinivasan, Andy Feinstein, Amol Khadikar, Jiani Zhang, Noémie Lauer, Hiral Shah, Sally Epstein, Jerome Buvat and Vaishnavee Ananth
      Since the proliferation of smartphones and social media in the late 2000s, digital has captured an increasingly large portion of the economy. In this Capgemini Research Institute report, The Eco-Digital EraTM: The dual transition to a sustainable and... View Details
      Keywords: Technology Adoption; Digital Transformation; Environmental Sustainability; Trends
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      Srinivasan, Suraj, Andy Feinstein, Amol Khadikar, Jiani Zhang, Noémie Lauer, Hiral Shah, Sally Epstein, Jerome Buvat, and Vaishnavee Ananth. "The Eco-Digital EraTM: The Dual Transition to a Sustainable and Digital Economy." Report, Capgemini Research Institute, January 2024.
      • December 2023 (Revised March 2024)
      • Case

      Manufacturing Moderna's Future

      By: Satish Tadikonda and William Marks
      In 2019, Moderna faced long odds of survival having failed to develop a successful clinical program out of the vast platform technology they had built around mRNA. Nearly overnight, the company skyrocketed to success with a vaccine for COVID-19, leading to an extremely... View Details
      Keywords: Health Pandemics; Health Testing and Trials; Technological Innovation; Product Development; Production; Science-Based Business; Biotechnology Industry
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      Tadikonda, Satish, and William Marks. "Manufacturing Moderna's Future." Harvard Business School Case 824-076, December 2023. (Revised March 2024.)
      • December 2023 (Revised February 2024)
      • Case

      Transforming Healthcare Delivery at Karolinska University Hospital

      By: Susanna Gallani, Mary Witkowski, Elena Corsi and Nikolina Jonsson
      The case study examines the journey toward value-based healthcare at Karolinska University Hospital. The hospital's ambitious shift to a patient-centered care delivery model, accompanied by the construction of a new facility, encountered challenges such as high costs,... View Details
      Keywords: Change Management; Transformation; Transition; Business Organization; Communication Strategy; Information Infrastructure; Service Delivery; Organizational Change and Adaptation; Organizational Structure; Health Industry; Sweden; Europe
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      Gallani, Susanna, Mary Witkowski, Elena Corsi, and Nikolina Jonsson. "Transforming Healthcare Delivery at Karolinska University Hospital." Harvard Business School Case 124-070, December 2023. (Revised February 2024.)
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