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  • 2024
  • Working Paper

Prozac—Controversial Blockbuster: Case Histories of Transformational Advances

By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
This case history describes the development of Prozac, a blockbuster drug that transformed the treatment of depression – and became a cultural phenomenon in the United States. Specifically, we chronicle the: 1) prior treatments for depression and the research that... View Details
Keywords: Health Care and Treatment; Technological Innovation; Innovation Strategy; Technology Adoption; Collaborative Innovation and Invention; Innovation and Invention; Governing Rules, Regulations, and Reforms
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Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "Prozac—Controversial Blockbuster: Case Histories of Transformational Advances." Harvard Business School Working Paper, No. 20-135, July 2020. (Revised May 2024.)
  • 2025
  • Working Paper

Gastrointestinal Endoscopy--Without Cutting In: Case Histories of Transformational Advances

By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
This case history describes how endoscopy transformed the diagnosis of ulcers, cancerous polyps, and other alimentary canal diseases and enabled “minimally invasive” surgeries to treat such diseases. Specifically, we chronicle how: 1) flexible glass fiber endoscopes... View Details
Keywords: Health Care and Treatment; Technological Innovation; Innovation Strategy; Technology Adoption; Collaborative Innovation and Invention; Innovation and Invention; Governing Rules, Regulations, and Reforms
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Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "Gastrointestinal Endoscopy--Without Cutting In: Case Histories of Transformational Advances." Harvard Business School Working Paper, No. 20-005, July 2019. (Revised January 2025.)
  • 02 Dec 2019
  • What Do You Think?

How Does a Company like Boeing Respond to Intense Competitive Pressure?

trying to avoid. It’s alleged that pressure was increasingly being applied by top management to meet cost and delivery targets. Sales had done a great job selling planes several years out at prices based on costs that it was thought would... View Details
Keywords: by James Heskett; Air Transportation
  • March 2014
  • Teaching Note

Uptake of Rapid Diagnostic Tests: A Development Challenge

By: Nava Ashraf, Andrew Boozary and Kristin Johnson
Keywords: Developing Countries and Economies; Health Pandemics; Technology; Health Care and Treatment; Policy; Behavior; Prejudice and Bias; Zambia
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Ashraf, Nava, Andrew Boozary, and Kristin Johnson. "Uptake of Rapid Diagnostic Tests: A Development Challenge." Harvard Business School Teaching Note 914-042, March 2014.
  • August 2021
  • Teaching Note

IBM Watson at MD Anderson Cancer Center

By: Shane Greenstein and Mel Martin
Teaching Note for HBS Case No. 621-022. View Details
Keywords: Decision Making; Technological Innovation; Innovation Strategy; Knowledge Management; Knowledge Use and Leverage; Operations; Failure; Information Technology; Applications and Software; Health Care and Treatment; Product Development; Health Industry; Health Industry; Health Industry; United States; Houston; Texas
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Greenstein, Shane, and Mel Martin. "IBM Watson at MD Anderson Cancer Center." Harvard Business School Teaching Note 622-020, August 2021.
  • 17 Oct 2017
  • First Look

First Look at New Research and Ideas, October 17, 2017

patient satisfaction, and problems with patient safety. Nearly all U.S. health care organizations have used similar evidence to justify their investments in safety and quality. Herein, we provide... View Details
Keywords: Sean Silverthorne
  • 23 Apr 2007
  • Research & Ideas

Are Great Teams Less Productive?

to help organizations better access, integrate, and leverage the talents and insights of their employees. An earlier career as an organizational change consultant led me to realize how many thoughtful, caring individuals were stymied in... View Details
Keywords: by Sarah Jane Gilbert
  • September 2018
  • Article

Discretionary Task Ordering: Queue Management in Radiological Services

By: Maria Ibanez, Jonathan R. Clark, Robert S. Huckman and Bradley R. Staats
Work-scheduling research typically prescribes task sequences implemented by managers. Yet employees often have discretion to deviate from their prescribed sequence. Using data from 2.4 million radiological diagnoses, we find that doctors prioritize similar tasks... View Details
Keywords: Discretion; Scheduling; Queue; Healthcare; Learning; Experience; Decentralization; Operations; Service Operations; Service Delivery; Performance; Performance Effectiveness; Performance Efficiency; Performance Improvement; Performance Productivity; Decisions; Time Management; Cost vs Benefits; Health Industry
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Ibanez, Maria, Jonathan R. Clark, Robert S. Huckman, and Bradley R. Staats. "Discretionary Task Ordering: Queue Management in Radiological Services." Management Science 64, no. 9 (September 2018): 4389–4407. (Working paper available here. Winner of the 2017 Best Paper Competition of the POMS College of Healthcare Operations Management. Featured in Forbes, Quartz, and Inc.)
  • 14 Feb 2017
  • First Look

First Look at New Research: February 14

institutionalized in America over subsequent decades in a way that has been difficult to replicate in other countries. The role of history helps to explain why. Publisher's link: https://www.hbs.edu/faculty/Pages/item.aspx?num=52209 December 8, 2016 Harvard Business... View Details
Keywords: Sean Silverthorne
  • 2017
  • Working Paper

Discretionary Task Ordering: Queue Management in Radiological Services

By: Maria Ibanez, Jonathan R. Clark, Robert S. Huckman and Bradley R. Staats
Work scheduling research typically prescribes task sequences implemented by managers. Yet employees often have discretion to deviate from their prescribed sequence. Using data from 2.4 million radiological diagnoses, we find that doctors prioritize similar tasks... View Details
Keywords: Discretion; Scheduling; Queue; Healthcare; Learning; Experience; Decentralization; Delegation; Behavioral Operations; Operations; Service Operations; Service Delivery; Performance; Performance Effectiveness; Performance Efficiency; Performance Improvement; Performance Productivity; Decisions; Time Management; Cost vs Benefits; Health Industry
Citation
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Ibanez, Maria, Jonathan R. Clark, Robert S. Huckman, and Bradley R. Staats. "Discretionary Task Ordering: Queue Management in Radiological Services." Harvard Business School Working Paper, No. 16-051, October 2015. (Revised March 2017.)
  • 12 Jun 2006
  • Research & Ideas

The Promise of Channel Stewardship

But in most scenarios, distribution channels, taken as a whole, seem more like a repository of lost opportunities than an effective delivery system that appropriately serves and rewards all participants. Powerful channel members routinely... View Details
Keywords: by V. Kasturi Rangan & Marie Bell; Consumer Products
  • Article

Use of Crowd Innovation to Develop an Artificial Intelligence-Based Solution for Radiation Therapy Targeting

By: Raymond H. Mak, Michael G. Endres, Jin Hyun Paik, Rinat A. Sergeev, Hugo Aerts, Christopher L. Williams, Karim R. Lakhani and Eva C. Guinan
Importance: Radiation therapy (RT) is a critical cancer treatment, but the existing radiation oncologist work force does not meet growing global demand. One key physician task in RT planning involves tumor segmentation for targeting, which requires substantial... View Details
Keywords: Crowdsourcing; AI Algorithms; Health Care and Treatment; Collaborative Innovation and Invention; AI and Machine Learning
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Mak, Raymond H., Michael G. Endres, Jin Hyun Paik, Rinat A. Sergeev, Hugo Aerts, Christopher L. Williams, Karim R. Lakhani, and Eva C. Guinan. "Use of Crowd Innovation to Develop an Artificial Intelligence-Based Solution for Radiation Therapy Targeting." JAMA Oncology 5, no. 5 (May 2019): 654–661.
  • August 2003 (Revised August 2006)
  • Case

I've Got Rhythm: Selling Cardiac Rhythm Management Devices

By: Regina E. Herzlinger, William Lagor, Christopher Perry and Scott St. Germain
The head of sales and marketing in a large medical devices firm must decide how to assign his sales force. He compares selling in the pharma, specialty pharma, and device industries and analyzes the reasons for the differences. View Details
Keywords: Health Care and Treatment; Marketing Strategy; Industry Structures; Sales; Salesforce Management; Medical Devices and Supplies Industry
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Herzlinger, Regina E., William Lagor, Christopher Perry, and Scott St. Germain. "I've Got Rhythm: Selling Cardiac Rhythm Management Devices." Harvard Business School Case 304-012, August 2003. (Revised August 2006.)
  • October 1992 (Revised September 1993)
  • Case

Nopane Advertising Strategy

By: David E. Bell
Nopane is a proprietary drug that sells in much of the United States. It faces substantial competition. The brand manager is undertaking an experiment to determine whether ad copy should be emotional-based or rational-based. The data and associated regression results... View Details
Keywords: Competition; Intellectual Property; Advertising; Health Care and Treatment; Brands and Branding; Product Marketing; Pharmaceutical Industry; United States
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Bell, David E. "Nopane Advertising Strategy." Harvard Business School Case 893-005, October 1992. (Revised September 1993.)
  • January 2023
  • Case

The END Fund: To Eliminate Neglected Tropical Diseases

By: V. Kasturi Rangan and Courtney Han
Founded in 2012, the END fund focused on eliminating five Neglected Tropical Diseases that accounted for 80% of the tropical diseases affecting nearly 1.5 billion people worldwide. Its roughly $25 million/year annual budget was fully committed when it got news that the... View Details
Keywords: Nonprofit Organizations; Health Disorders; Health Care and Treatment; Resource Allocation; Global Range; Decisions; Investment Funds
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Rangan, V. Kasturi, and Courtney Han. "The END Fund: To Eliminate Neglected Tropical Diseases." Harvard Business School Case 523-063, January 2023.
  • 25 Oct 2016
  • First Look

October 25, 2016

Healthcare Group Acıbadem Healthcare Group is Turkey's only premium nationwide hospital network. This case focuses on Acıbadem’s potential expansion strategy after it was acquired by International Healthcare Holdings Berhad (IHH) in 2011, the world's second-largest... View Details
Keywords: Sean Silverthorne
  • 24 May 2011
  • First Look

First Look: May 24

http://www.hbs.edu/research/pdf/11-031.pdf Measuring Teamwork in Health Care Settings: A Review of Survey Instruments Authors:Melissa A. Valentine, Ingrid M. Nembhard, and Amy C. Edmondson Abstract... View Details
Keywords: Sean Silverthorne
  • 09 Jul 2008
  • Research & Ideas

Starbucks’ Lessons for Premium Brands

in three ways. First, the early adopters who valued the club-like atmosphere of relaxing over a quality cup of coffee found themselves in a minority. To grow, Starbucks increasingly appealed to grab and go customers for whom service meant speed of order View Details
Keywords: by John Quelch; Retail
  • 01 Apr 2008
  • First Look

First Look: April 1, 2008

which, as the former parent of Delphi, has agreed to fund a portion of the massive pension and retiree health care liabilities that Delphi incurred when it separated from GM in a prior spin-off. The company... View Details
Keywords: Martha Lagace
  • 06 Mar 2018
  • First Look

First Look at Research and Ideas, March 6, 2018

https://www.hbs.edu/faculty/Pages/item.aspx?num=52341 February 20, 2018 JAMA, the Journal of the American Medical Association Administrative Costs Associated with Physician Billing and Insurance-Related Activities at an Academic Health... View Details
Keywords: Sean Silverthorne
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