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  • 29 Aug 2006
  • First Look

First Look: August 29, 2006

the firm-size distribution; controlling for level of economic development, regulation, institutional constraints, and other variables that might affect the business environment; and using different empirical specifications. We further... View Details
Keywords: Sean Silverthorne
  • 12 Jun 2018
  • First Look

New Research and Ideas, June 12, 2018

money using their mobile phones. Mobile money has grown quickly, but high stockout rates of currency persist due to suboptimal inventory decisions made by contracted employees (called agents). In partnership with a Tanzanian mobile money operator, we perform a View Details
Keywords: Dina Gerdeman
  • 25 Feb 2020
  • News

Alumni and Faculty Books for March 2020

impact of changes to an experience or product. Once an esoteric tool for academic research, the randomized controlled trial has gone mainstream—and is becoming an important... View Details
  • June 2023 (Revised July 2024)
  • Case

Biogen and the Aduhelm Melee

By: Amitabh Chandra and Lauren Gunasti
Alzheimer's Disease is a devastating condition affecting millions of Americans. At this time, there is no cure. In 2021, Biogen's Aduhelm (aducanumab) received FDA approval under the accelerated approval pathway after a controversial approval process.

This... View Details
Keywords: Health Testing and Trials; Governing Rules, Regulations, and Reforms; Valuation; Product Development; Pharmaceutical Industry
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  • 01 Dec 2010
  • News

Chaotic Funding Derails Research

randomized model of research support in the United States, in which a change in administration or a court ruling can outlaw work that was previously supported by the government. Funding can be canceled with the stroke of a pen. The... View Details
Keywords: William Sahlman; Science funding; stem cell research; Colleges, Universities, and Professional Schools; Educational Services
  • 21 Aug 2012
  • Research & Ideas

How to Sink a Startup

Tim Westergren of Pandora and Evan Williams of Twitter. YouTube cofounder and former CEO Chad Hurley has called the book "an invaluable alternative to real-world trial and error." A past recipient of the HBS student-voted award for... View Details
Keywords: by Garry Emmons
  • 2010
  • Chapter

From Visible Harm to Relative Risk: Centralization and Fragmentation of Pharmacovigilance

By: Arthur A. Daemmrich
Adverse drug reactions pose distinct but potentially catastrophic risks to patients, physicians, pharmaceutical firms, and regulators. Between the early 1960s and the present, national systems were built to collect, standardize, and respond to individual reports of... View Details
Keywords: Governing Rules, Regulations, and Reforms; Health Testing and Trials; Business and Government Relations; Risk and Uncertainty; Safety; Pharmaceutical Industry; United States
Related
  • 14 Dec 2020
  • Research & Ideas

What Does December's Drug-Approval Dash Mean for COVID-19 Vaccines?

aspects of the drug trial and approval process, including allowing time for potential issues to materialize. When you see an FDA emergency approval for a COVID-19 vaccine, don't interpret this as a normal “FDA approval.” I understand that... View Details
Keywords: by Danielle Kost; Pharmaceutical; Health
  • 10 Nov 2015
  • First Look

November 10, 2015

communication and collaboration between practitioners and academics by introducing key vocabulary and concepts used in rigorous impact evaluation methods, starting with randomized controlled View Details
Keywords: Sean Silverthorne
  • 02 Nov 2010
  • First Look

First Look: November 2, 2010

perceived agreeableness; the decrease in leadership effectiveness perception between moderate and high decision latitude was explained by a decrease in perceived conscientiousness. Theoretical and practical implications of these findings are discussed. Keeping the... View Details
Keywords: Sean Silverthorne
  • February 2013
  • Article

An Activity-Generating Theory of Regulation

By: Joshua Schwartzstein and Andrei Shleifer
We propose an activity-generating theory of regulation. When courts make errors, tort litigation becomes unpredictable and as such imposes risk on firms, thereby discouraging entry, innovation, and other socially desirable activity. When social returns to activity are... View Details
Keywords: Courts and Trials; Lawsuits and Litigation; Governing Rules, Regulations, and Reforms; Theory
Related
  • 09 Dec 2014
  • First Look

First Look: December 9

experiment and their interactions can make it difficult to determine cause-and-effect relationships. Choosing the right sample size is important. How can we ensure reliable results? Randomized field trials, "blind" tests, and... View Details
Keywords: Sean Silverthorne
  • 09 Feb 2010
  • First Look

First Look: Feb. 9

both proprietary and shared platforms toward hybrid governance models characterized by centralized control over platform technology (i.e., closed sponsorship) and shared responsibility for serving users (i.e., an open provider role).... View Details
Keywords: Martha Lagace
  • 21 Jul 2006
  • Op-Ed

Enron Jury Sent the Right Message

The most noteworthy message of the Enron trial is that corporate executives can be convicted in a court of law for a pattern of deception that may or may not be illegal. Left unaddressed in the trial were... View Details
Keywords: by Malcolm S. Salter
  • 02 Jun 2011
  • Research & Ideas

Signing at the Top: The Key to Preventing Tax Fraud?

end of the tax form, after the form has been filled out and, consequently, after the potential cheating has occurred. (It's analogous to a witness first testifying in a court trial and then swearing on a Bible, "For the last twenty... View Details
Keywords: by Carmen Nobel; Accounting
  • 03 Nov 2015
  • First Look

November 3, 2015

at facilitating communication and collaboration between practitioners and academics by introducing key vocabulary and concepts used in rigorous impact evaluation methods, starting with randomized controlled... View Details
Keywords: Sean Silverthorne
  • 17 Mar 2009
  • First Look

First Look: March 17, 2009

Microfinance in particular has often been argued, but not without controversy, to be a tool for empowering women. Here, using a randomized controlled trial, we examine whether access to, and marketing of, an... View Details
Keywords: Martha Lagace
  • 01 Jun 2012
  • News

Pitfalls, Trade-Offs, Dreaming Big

entrepreneurs such as Tim Westergren of Pandora and Evan Williams of Twitter. YouTube cofounder and former CEO Chad Hurley has called the book “an invaluable alternative to real-world trial and error.” A past recipient of the HBS... View Details
Keywords: Garry Emmons; Health, Social Assistance; Data Processing, Hosting, and Related Services; Information; News, Library, Internet, and Other Services; Information
  • Web

Teaching Cases - Institute For Strategy And Competitiveness

joint venture with a community hospital to establish Hoag Orthopedic Institute, a for-profit hospital and two ambulatory service centers. By controlling and integrating all aspects of the patients' medical treatment, the physicians... View Details
  • 30 Jan 2012
  • Research & Ideas

Measuring the Efficacy of the World’s Managers

larger number of organizations. The researchers have also started to work on management experiments, modeled on the randomized control trials adopted in the medical field. This... View Details
Keywords: by Carmen Nobel