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  • November 2009 (Revised March 2010)
  • Case

Managing Drugs on the Forefront of Personalized Medicine: The Erbitux and Vectibix Story

By: Richard G. Hamermesh, Raju Kucherlapati and Rachel Gordon
In May 2007, Amgen Inc. (Amgen) received disappointing news from the European Medicines Agency (EMEA) that its drug Vectibix, developed to fight metastatic colorectal cancer, had been rejected. This was especially surprising news given that a similar rival drug had... View Details
Keywords: Entrepreneurship; Governing Rules, Regulations, and Reforms; Health Testing and Trials; Marketing Strategy; Product Positioning; Genetics; Biotechnology Industry; Europe; United States
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  • 05 Nov 2024
  • Research & Ideas

AI Can Help Leaders Communicate, But Can't Make Employees Listen

London’s School of Management, and Amirhossein Zohrehvand, assistant professor at Leiden University. Turing, meet Wade The Turing Test is an imitation game in which a person must guess whether they’re communicating with a machine or another person; if their success... View Details
Keywords: by Ben Rand; Information Technology; Technology
  • 01 Aug 2017
  • First Look

First Look at New Research and Ideas, August 1

Abstract—Objective: Assess whether a commitment contract informed by behavioral economics leads to persistent virologic suppression among HIV-positive patients with poor antiretroviral therapy (ART) adherence. Design: Single-center pilot View Details
Keywords: Sean Silverthorne
  • 01 May 2007
  • First Look

First Look: May 1, 2007

that firms focusing on a particular task—at either a divisional or firm level—experience higher output and productivity with respect to that task than unfocused firms. After controlling for selection, scale, and learning effects, we find... View Details
Keywords: Sean Silverthorne
  • 17 Mar 2009
  • First Look

First Look: March 17, 2009

Microfinance in particular has often been argued, but not without controversy, to be a tool for empowering women. Here, using a randomized controlled trial, we examine whether access to, and marketing of, an... View Details
Keywords: Martha Lagace
  • 17 Sep 2013
  • First Look

First Look: September 17

recommendations for stocks with larger market capitalizations and lower return volatility than their sell-side peers, consistent with their facing fewer conflicts of interest and having a preference for liquid stocks. Tests with no View Details
Keywords: Sean Silverthorne
  • 24 Jul 2019
  • Lessons from the Classroom

Can These Business Students Motivate Londoners to Do the Right Thing?

unintended consequences..." The approach has really taken hold in policy settings, and there are now many teams in governments focused on bringing behavioral insights and randomized controlled View Details
Keywords: by Dina Gerdeman
  • 2013
  • Working Paper

What Makes the Bonding Stick? A Natural Experiment Involving the U.S. Supreme Court and Cross-Listed Firms

By: Amir N. Licht, Christopher Poliquin, Jordan I. Siegel and Xi Li
On March 29, 2010, the U.S. Supreme Court signaled its intention to geographically limit the reach of the U.S. securities antifraud regime and thus differentially exclude U.S.-listed foreign firms from the ambit of formal U.S. antifraud enforcement. We use this legal... View Details
Keywords: Crime and Corruption; International Finance; Investment; Corporate Governance; Governing Rules, Regulations, and Reforms; Courts and Trials; Legal Liability; United States
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  • 20 Sep 2011
  • First Look

First Look: September 20

likelihood that they will exploit their current exchange partners, even after controlling for the leverage provided by the outside options. Our results demonstrate that previously sunken investments lead to a heightened sense of... View Details
Keywords: Sean Silverthorne
  • 17 Jul 2012
  • First Look

First Look: July 17

institutional appropriateness was the stronger requirement; the lack of it prevented an otherwise informationally relevant risk control system from prevailing as an interactive control system. Download the... View Details
Keywords: Sean Silverthorne
  • 13 Feb 2013
  • Research & Ideas

5 Weight Loss Tips From Behavioral Economists

The researchers found that the financial incentive group lost significantly more weight in 32 weeks than did the control group. (Unfortunately, much of the weight came back after the eight-month trial was... View Details
Keywords: by Carmen Nobel
  • 10 Oct 2000
  • Research & Ideas

Cross-Sector Collaboration: Lessons from the International Trachoma Initiative

scientific field of trachoma control forward and now had the opportunity to "finish the job." That is, it could help to make operational its research in a way that directly improved the lives of disadvantaged people, the core... View Details
Keywords: by Diana Barrett, James Austin & Sheila McCarthy
  • 27 Jun 2017
  • First Look

First Look at New Research and Ideas, June 27

challenging in the past, and remains so today, the book argues that one reason was how they have both been defined. Publisher's link: https://www.hbs.edu/faculty/Pages/item.aspx?num=52778 forthcoming Journal of International Economics The Real Effects of Capital View Details
Keywords: Sean Silverthorne
  • 10 May 2016
  • First Look

May 10, 2016

Publisher's link: https://www.hbs.edu/faculty/Pages/item.aspx?num=51040 forthcoming American Journal of Health Promotion The Effect of Cost Sharing on an Employee Weight Loss Program: A Randomized Trial By:... View Details
Keywords: Carmen Nobel
  • 20 Dec 2016
  • First Look

December 20, 2016

artificial worlds for hypothesis testing and theory building. Agent-based models (ABMs) offer unprecedented control and statistical power by allowing researchers to precisely specify the behavior of any number of agents and observe their... View Details
Keywords: Carmen Nobel
  • 23 May 2017
  • First Look

First Look at New Ideas and Research: May 23, 2017

substantial variation exists across organizations with regard to management, suggesting frictions in the broader diffusion of management knowledge. We argue that peer networks may allow for the diffusion of productive management across firms. Using a View Details
Keywords: Carmen Nobel
  • 01 Dec 2021
  • What Do You Think?

How Will the Metaverse Affect Productivity?

takes away productivity." Fans of the television show, Alter Ego, in which avatars controlled by contestants competing to become the next pop star, would argue that Alter Ego is little more than an introduction to the Metaverse. They’re... View Details
Keywords: by James Heskett
  • 25 Apr 2012
  • What Do You Think?

How Will the “Age of Big Data” Affect Management?

of direct process control in which decisions have to be made "in the flow" in situations where there isn't time for conventional analysis (at least by humans). Is this a glimpse into the future of decision-making (without analysis... View Details
Keywords: Re: James L. Heskett
  • 06 Jan 2011
  • What Do You Think?

How Should Management Deal With “Anonymous”?

intended victim. (Ironically, in the meantime we have learned that the "worm" that attacked Iran's nuclear centrifuges and sent them whirling out of control and into self-destruction in all likelihood was carefully engineered... View Details
Keywords: by James L. Heskett
  • December 2006 (Revised August 2008)
  • Case

Pervasis Therapeutics, Inc.

By: Robert F. Higgins and Virginia Fuller
In May 2005, Steve Bollinger was about to become president and chief operating officer of Pervasis Therapeutics, a small cell therapy start-up in Cambridge, Mass. If proven successful, Pervasis' product, Vascugel, could change the way vascular disease is treated and... View Details
Keywords: Business Startups; Venture Capital; Financial Strategy; Governing Rules, Regulations, and Reforms; Health Care and Treatment; Health Testing and Trials; Health Industry; Cambridge
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