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      • 2004
      • Article

      Do Firms Change Capabilities by Hiring New People? A Study of the Adoption of Science-based Drug Discovery

      By: Rebecca M. Henderson, Nicola Lacetera and Iain Cockburn
      Keywords: Selection and Staffing; Change; Science; Health; Information
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      Henderson, Rebecca M., Nicola Lacetera, and Iain Cockburn. "Do Firms Change Capabilities by Hiring New People? A Study of the Adoption of Science-based Drug Discovery." Advances in Strategic Management 21 (2004).
      • August 2003 (Revised August 2024)
      • Case

      Fighting the Battle of the Bulge—Evaluating Do Good/Do Well Innovations in Morbid Obesity Treatment

      By: Regina E. Herzlinger and John McDonough
      Many health care innovations appear successful; but fail. This is the first case in the Innovating Health Care course that investigates how to create successful health care innovations. It is part of the first module in the course. This module focuses on how to... View Details
      Keywords: Three Pillars; Industry Analysis; Health Care and Treatment; Innovation and Invention; Innovation and Management; Medical Specialties; Health Industry
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      Herzlinger, Regina E., and John McDonough. "Fighting the Battle of the Bulge—Evaluating Do Good/Do Well Innovations in Morbid Obesity Treatment." Harvard Business School Case 304-009, August 2003. (Revised August 2024.)
      • June 2003 (Revised May 2006)
      • Case

      Cipla

      By: Rohit Deshpande and Laura Winig
      The head of Cipla, a $325-million-dollar Indian pharmaceutical company and seller of low-cost AIDS drugs to South Africa, must decide what to do about Cipla's future. With India poised to enforce international patents in only two years, much of Cipla's product line... View Details
      Keywords: Trade; Price; Global Strategy; Health Care and Treatment; Patents; Leadership; Marketing Strategy; Health Industry; South Africa; India
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      Deshpande, Rohit, and Laura Winig. "Cipla." Harvard Business School Case 503-085, June 2003. (Revised May 2006.)
      • April 2003 (Revised October 2004)
      • Case

      Novartis: The Challenge of Success (A)

      By: Sandra J. Sucher and Stacy McManus
      Preliminary results from Phase 1 clinical trials of a newly developed compound, STI571, showed that 31 out of 31 patients with chronic myelogenous leukemia (CML) had their blood counts return to normal. In the world of oncology, this was unheard of. This was the... View Details
      Keywords: Decision Making; Health Testing and Trials; Innovation and Invention; Markets; Distribution; Product Development; Production; Problems and Challenges; Research; Research and Development; Complexity; Biotechnology Industry; Pharmaceutical Industry
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      Sucher, Sandra J., and Stacy McManus. "Novartis: The Challenge of Success (A)." Harvard Business School Case 603-043, April 2003. (Revised October 2004.)
      • February 2003 (Revised April 2004)
      • Case

      Pharmaceutical Industry, The: Challenges in the New Century

      By: Stephen P. Bradley and James Weber
      Provides a broad overview of the numerous internal and external forces that were driving change in the global pharmaceutical industry in 2003. These forces--including downward price pressures, political and social pressures, increased development costs, new... View Details
      Keywords: Business Model; Change; Cost; Price; Globalization; Government and Politics; Brands and Branding; Industry Growth; Society; Competition; Consolidation; Technology; Pharmaceutical Industry
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      Bradley, Stephen P., and James Weber. "Pharmaceutical Industry, The: Challenges in the New Century." Harvard Business School Case 703-489, February 2003. (Revised April 2004.)
      • September 2002 (Revised August 2003)
      • Case

      Genzyme's Gaucher Initiative: Global Risk and Responsibility

      By: Christopher A. Bartlett and Andrew N. McLean
      In Egypt, Genzyme's humanitarian commitment to treat all sufferers of the rare Gaucher disease worldwide first confronts its commercial imperative to recoup the huge investment required to bring the drug Cerezyme to market. Here Tomye Tierney must decide how to balance... View Details
      Keywords: Moral Sensibility; Investment; Emerging Markets; Negotiation; Corporate Social Responsibility and Impact; Business and Government Relations; Sales; Commercialization; Expansion; Value Creation
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      Bartlett, Christopher A., and Andrew N. McLean. "Genzyme's Gaucher Initiative: Global Risk and Responsibility." Harvard Business School Case 303-048, September 2002. (Revised August 2003.)
      • July 2002
      • Article

      Asset Accumulation, Interdependence and Technological Change: Evidence from Pharmaceutical Drug Discovery

      By: Stefan Thomke and Walter Kuemmerle
      Keywords: Assets; Information Technology; Change; Health
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      Thomke, Stefan, and Walter Kuemmerle. "Asset Accumulation, Interdependence and Technological Change: Evidence from Pharmaceutical Drug Discovery." Strategic Management Journal 23, no. 7 (July 2002): 619–635.
      • June 2002 (Revised November 2005)
      • Case

      Life, Death, and Property Rights: The Pharmaceutical Industry Faces AIDS in Africa

      By: Debora L. Spar
      In the final years of the 20th century, the world was hit by a plague of epidemic proportions--AIDS, a life-threatening disease that remained stubbornly immune to any cure or vaccine. In the developed nations of the West, AIDS was slowly brought under control through a... View Details
      Keywords: Patents; Health Pandemics; Corporate Social Responsibility and Impact; Pharmaceutical Industry; Africa
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      Spar, Debora L., and Nick Bartlett. "Life, Death, and Property Rights: The Pharmaceutical Industry Faces AIDS in Africa." Harvard Business School Case 702-049, June 2002. (Revised November 2005.)
      • May 2002 (Revised October 2005)
      • Case

      Marketing Antidepressants: Prozac and Paxil

      By: Youngme E. Moon and Kerry Herman
      Describes the marketing of Prozac and Paxil, two of the best-selling mental health drugs in history. Set in 2001, several months before the expiration of Prozac's patent, Eli Lilly (Prozac's manufacturer) and GlaxoSmithKline (Paxil's manufacturer) must decide how to... View Details
      Keywords: Patents; Product Positioning; Competition; Ethics; Value; Health Care and Treatment; Brands and Branding; Pharmaceutical Industry; United States
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      Moon, Youngme E., and Kerry Herman. "Marketing Antidepressants: Prozac and Paxil." Harvard Business School Case 502-055, May 2002. (Revised October 2005.)
      • April 2002
      • Case

      In vivo to in vitro to in silico: Coping with Tidal Waves of Data at Biogen

      By: Juan Enriquez-Cabot, Gary P. Pisano and Gaye Bok
      Biogen is a successful biotech company facing a critical juncture. CEO John Mullen ponders how technological changes introduced into the research function will shape larger corporate decisions. This world in which biotechnology companies operated had changed... View Details
      Keywords: Change; Decisions; Product Development; Research and Development; Expansion; Technology; Biotechnology Industry
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      Enriquez-Cabot, Juan, Gary P. Pisano, and Gaye Bok. "In vivo to in vitro to in silico: Coping with Tidal Waves of Data at Biogen." Harvard Business School Case 602-122, April 2002.
      • February 2002
      • Case

      Fighting AIDS and Pricing Drugs

      By: John T. Gourville
      In early 2001, makers of AIDS drugs were suing to prevent developing countries from violating their patents. The issue was driven by price. The developing countries could not afford the market price for these drugs. At the same time, the drug companies were reluctant... View Details
      Keywords: Developing Countries and Economies; Patents; Price; Strategy; Globalized Markets and Industries; Pharmaceutical Industry
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      Gourville, John T. "Fighting AIDS and Pricing Drugs." Harvard Business School Case 502-061, February 2002.
      • September 2001 (Revised October 2001)
      • Teaching Note

      Merck & Company: Evaluating A Drug Licensing Opportunity TN

      By: Richard S. Ruback and Aldo Sesia
      Teaching Note for (9-201-023). View Details
      Keywords: Service Industry
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      Ruback, Richard S., and Aldo Sesia. "Merck & Company: Evaluating A Drug Licensing Opportunity TN." Harvard Business School Teaching Note 202-001, September 2001. (Revised October 2001.)
      • August 2001 (Revised March 2008)
      • Case

      Helios Health (A)

      By: Regina E. Herzlinger and Alfred Martin
      Helios PC system provides personalized drug information to the patients in the doctor's waiting room. It has met with considerable consumer acceptance and a very high return for the drug companies that sponsor it. What price should it charge them for the service? View Details
      Keywords: Entrepreneurship; Price; Health Care and Treatment; Information Publishing; Innovation and Invention; Product Marketing; Demand and Consumers; Health Industry; Pharmaceutical Industry
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      Herzlinger, Regina E., and Alfred Martin. "Helios Health (A)." Harvard Business School Case 302-022, August 2001. (Revised March 2008.)
      • July 2001 (Revised August 2005)
      • Case

      Medicines Company, The

      By: John T. Gourville
      It is early 2001 and the Medicines Co. just received FDA approval to market Angiomax, a blood thinner to be used during angioplasties and heart procedures. It is intended to be a better alternative to Heparin, an 80-year-old drug that costs less then $10 per dose. The... View Details
      Keywords: Business Model; Change Management; Decision Choices and Conditions; Cost Management; Price; Product Marketing; Product Launch; Product Development; Risk and Uncertainty; Health Industry; Pharmaceutical Industry
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      Gourville, John T. "Medicines Company, The." Harvard Business School Case 502-006, July 2001. (Revised August 2005.)
      • 2001
      • Working Paper

      Asset Accumulation, Interdependence and Technological Change: Evidence from Pharmaceutical Drug Discovery

      By: Stefan Thomke and Walter Kuemmerle
      Citation
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      Thomke, Stefan, and Walter Kuemmerle. "Asset Accumulation, Interdependence and Technological Change: Evidence from Pharmaceutical Drug Discovery." Harvard Business School Working Paper, No. 00-086, July 2001.
      • June 2001
      • Supplement

      Merck & Company: Evaluating a Drug Licensing Opportunity

      By: Richard S. Ruback
      Spreadsheet to (9-201-023). Download only. View Details
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      Ruback, Richard S. "Merck & Company: Evaluating a Drug Licensing Opportunity." Harvard Business School Spreadsheet Supplement 201-707, June 2001.
      • February 2001 (Revised July 2006)
      • Case

      Discovering the Future: R&D Strategy at Merck

      By: Gary P. Pisano
      Given explosive growth in technologies for drug discovery, how does Merck remain competitive in an industry that is fragmented and continues to consolidate? View Details
      Keywords: Competitive Strategy; Research and Development; Pharmaceutical Industry
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      Pisano, Gary P. "Discovering the Future: R&D Strategy at Merck." Harvard Business School Case 601-086, February 2001. (Revised July 2006.)
      • January 2001
      • Case

      Merck Global Health Initiatives (A)

      By: James E. Austin, Diana Barrett and James Weber
      The case series focuses on Merck's drug donation program and then raises new issues facing management about what to do about HIV/AIDS in Africa given the company's development of a new therapy. Describes collaboration among many parties including the Gates Foundation,... View Details
      Keywords: Programs; Philanthropy and Charitable Giving; Health Disorders; Health Care and Treatment; Private Sector; Public Sector; Alliances; Problems and Challenges; Pharmaceutical Industry; Botswana
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      Austin, James E., Diana Barrett, and James Weber. "Merck Global Health Initiatives (A)." Harvard Business School Case 301-088, January 2001.
      • January 2001
      • Case

      Merck Global Health Initiatives (B): Botswana

      By: James E. Austin, Diana Barrett and James Weber
      The case series focuses on Merck's drug donation program and then raises new issues facing management about what to do about HIV/AIDS in Africa given the company's development of a new therapy. Describes collaboration among many parties including the Gates Foundation,... View Details
      Keywords: Health Disorders; Health Care and Treatment; Private Sector; Public Sector; Alliances; Problems and Challenges; Africa; Botswana
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      Austin, James E., Diana Barrett, and James Weber. "Merck Global Health Initiatives (B): Botswana." Harvard Business School Case 301-089, January 2001.
      • January 2001 (Revised July 2003)
      • Case

      Pharmacyclics: Financing Research & Development

      By: Malcolm P. Baker, Richard S. Ruback and Aldo Sesia
      Pharmacyclics (NASDAQ: PCYC), a pharmaceutical company that manufactures products that will improve existing therapeutic treatments for cancer, arteriosclerosis, and retinal disease, was considering a $60 million private placement in February 2000. The company had more... View Details
      Keywords: Valuation; Cash Flow; Financing and Loans; Business Startups; Financial Strategy; Medical Devices and Supplies Industry; Pharmaceutical Industry; Health Industry
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      Baker, Malcolm P., Richard S. Ruback, and Aldo Sesia. "Pharmacyclics: Financing Research & Development." Harvard Business School Case 201-056, January 2001. (Revised July 2003.)
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