adaptation - Publications - Faculty & Research

September 2017 (Revised July 2023)
Case

Adaptive Platform Trials: The Clinical Trial of the Future?

By: Ariel D. Stern and Sarah Mehta

In July 2017, Dr. Brian M. Alexander, president and CEO of the AGILE Research Foundation, was preparing to launch a new type of clinical trial—an adaptive platform trial—to study potential therapies for glioblastoma (GBM), an aggressive form of brain cancer.... View Details

Keywords: Clinical Trials; Cancer; Adaptive Platform Trials; Platform Trials; Adaptive Trials; Glioblastoma; Health; Health Care and Treatment; Health Testing and Trials; Business Strategy; Innovation Strategy; Health Industry; United States

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October 2019
Article

Adaptive Platform Trials: Definition, Design, Conduct and Reporting Considerations

By: Derek C. Angus, Brian M. Alexander, Scott Berry, Meredith Buxton, Roger Lewis, Melissa Paoloni, Steven A. R. Webb, Steven Arnold, Anna Barker, Donald A. Berry, Marc J. M. Bonten, Mary Brophy, Christopher Butler, Timothy F. Cloughesy, Lennie P. G. Derde, Laura J. Esserman, Ryan Ferguson, Louis Fiore, Sarah C. Gaffey, J. Michael Gaziano, Kathy Giusti, Herman Goossens, Stephane Heritier, Bradley Hyman, Michael Krams, Kay Larholt, Lisa M. LaVange, Philip Lavori, Andrew W. Lo, Alexander J. London, Victoria Manax, Colin McArthur, Genevieve O’Neill, Giovanni Parmigiani, Jane Perlmutter, Elizabeth A. Petzold, Craig Ritchie, Kathryn M. Rowan, Christopher W. Seymour, Nathan I. Shapiro, Diane M. Simeone, Bradley Smith, Bradley Spellberg, Ariel Dora Stern, Lorenzo Trippa, Mark Trusheim, Kert Viele, Patrick Y. Wen and Janet Woodcock

Researchers, clinicians, policymakers, and patients are increasingly interested in questions about therapeutic interventions that are difficult or costly to answer with traditional, free-standing, parallel-group randomized controlled trials (RCTs). Examples include... View Details

Keywords: Adaptive Platform Trials; Health Testing and Trials

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September 2019
Supplement

Adaptive Platform Trials: The Clinical Trial of the Future? (B)

By: Ariel D. Stern and Sarah Mehta

This case provides an update to the (A) case, which introduces students to adaptive platform trials, an ambitious, more efficient type of clinical trial that increases access to therapies. The (A) case centers on Dr. Brian Alexander’s efforts to launch an adaptive... View Details

Keywords: Clinical Trials; Drug Trials; Drug Testing; Cancer Trials; Glioblastoma; Platform Trials; Adaptive Trials; Adaptive Platform Trials; Health Testing and Trials; Health Care and Treatment; Financing and Loans; Business Strategy; Health Industry; United States

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July 2021
Supplement

Adaptive Platform Trials: The Clinical Trial of the Future? (C)

By: Ariel D. Stern and Sarah Mehta

This (C) case provides an update on the work of the Global Coalition for Adaptive Research (GCAR) and also illustrates how adaptive platform trials can nimbly respond to a global pandemic. View Details

Keywords: Clinical Trials; Drug Trials; Drug Testing; Cancer Trials; Glioblastoma; Platform Trials; Adaptive Trials; Adaptive Platform Trials; Health Testing and Trials; Health Care and Treatment; Business Strategy; Health Industry; United States

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Article

Adaptive Machine Unlearning

By: Varun Gupta, Christopher Jung, Seth Neel, Aaron Roth, Saeed Sharifi-Malvajerdi and Chris Waites

Data deletion algorithms aim to remove the influence of deleted data points from trained models at a cheaper computational cost than fully retraining those models. However, for sequences of deletions, most prior work in the non-convex setting gives valid guarantees... View Details

Keywords: Machine Learning; AI and Machine Learning

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August 2011 (Revised November 2017)
Case

Adaptive Engineering, LLC

By: Richard S. Ruback and Royce Yudkoff

The owner and CEO of Adaptive Engineering was facing an important decision: should he focus on rebuilding its core professional services business which had generated significant revenue and cash flow over the past several years, or should he focus on developing and... View Details

Keywords: Leadership; Growth and Development Strategy; Decision Making; Service Industry; Technology Industry

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March 2018
Teaching Note

Adaptive Platform Trials: The Clinical Trial of the Future?

By: Ariel D. Stern and Sarah Mehta

This teaching note provides guidance and recommendations for teaching HBS Case No. 618-025, entitled “Adaptive Platform Trials: The Clinical Trial of the Future?” View Details

Keywords: Clinical Trials; Drug Trials; Drug Testing; Cancer Trials; Glioblastoma; Platform Trials; Adaptive Trials; Adaptive Platform Trials; Health Testing and Trials; Health Care and Treatment; Business Strategy; Health Industry; United States

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Research Summary

Climate Adaptation

By: John D. Macomber

It's clear that challenges like wildfires, river flooding, extreme heat, and storm surge are increasing. How will homeowners, businesses, instituations, goverments, and all of society decide what and whom to protect and what and whom to not protect? What is the timing?... View Details

Keywords: Climate Change; Climate Risk; Hurricanes; Fire Protection; Water Management; Insurance And Reinsurance

06 Aug 2012
Research & Ideas

Strategic Intelligence: Adapt or Die

corporate strategy, Wells has learned that the seeds of failure are often planted years before they sprout, and only by overcoming complacency and constantly adapting to the changing competitive environment can companies prosper in the... View Details

Keywords: by Michael Blanding

October–December 2022
Article

How Psychological Safety and Feeling Heard Relate to Burnout and Adaptation Amid Uncertainty

By: Michaela J. Kerrissey, Tuna Cem Hayirli, Aditi Bhanja, Nicholas Stark, James Hardy and Christopher Peabody

Background: Psychological safety—the belief that it is safe to speak up—is vital amid uncertainty, but its relationship to feeling heard is not well understood.
Purpose: The aims of this study were (a) to measure feeling heard and (b) to assess... View Details

Keywords: Burnout; Crisis; Psychological Safety; Feeling Heard; Process Adaptation; Interpersonal Communication; Well-being; Health Care and Treatment; Adaptation

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06 Aug 2012
News

Strategic Intelligence: Adapt or Die

07 May 2020
Video

Innovative Mitigation and Adaptation Strategies

04 Mar 2020

Innovative Mitigation and Adaptation Strategies

Teaching Interest

Business Opportunties in Climate Adaptation

By: John D. Macomber

This is a Short Intensive Program or SIP at Harvard Business School. It’s an optional student offering prior to the formal start of the Spring semester the following week. SIPs tend to cover new material on current topics, to be less formal than the HBS Case Study... View Details

Keywords: Resilience; Climate Risk; Climate Impact; Fire Protection; Insurance Risk Exposure; Hedge Fund; Public Health; Public Health Measures; Climate Change; Adaptation; Infrastructure; Real Estate Industry; Transportation Industry; Insurance Industry; United States; Africa; Latin America

04 May 2010
News

The advantages of adaptation

01 Dec 2014
News

Nimble, Quick, and Adaptable

(Sergey Nivens/iStock/Thinkstock) Starting a business, says HBS professor Tom Eisenmann, looks glamorous in The Social Network. “But a fair amount of it is moving boxes around. Not org chart boxes—actual boxes.” That’s the kind of insight Eisenmann says students get... View Details

Keywords: Julia Hanna