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October 2024 (Revised October 2024)
Case

SWEN Blue Ocean: Impact Investing Goes to Sea

By: Vikram S Gandhi and David Allen

In August 2023, SWEN Blue Ocean, a €170 million impact fund that invested in startups contributing to ocean sustainability, faced a critical investment decision. Part of SWEN Capital Partners, an €8 billion, Paris-based private equity fund, Blue Ocean was co-founded in... View Details

Keywords: Communication Technology; Environmental Sustainability; Green Technology; Finance; Capital; Venture Capital; Private Equity; Investment; Investment Funds; Science-Based Business; Financial Services Industry; France; Paris; Italy

September 2024
Case

Myeloma Investment Fund

By: Kyle Myers and Scott Sawaya

This case explores a critical decision facing the Myeloma Investment Fund (MIF) as it evaluates two investment opportunities aimed at accelerating a cure for multiple myeloma. The MIF, a venture philanthropy fund, must choose between two distinct paths. One option... View Details

Keywords: Venture Philanthropy; Biomedical Research; Science Bassed Business; Investing For Impact; Innovation ＆ Entrepreneurship; Venture Capital; Science-Based Business; Biotechnology Industry; Pharmaceutical Industry

March 2024 (Revised July 2024)
Case

WeightWatchers: Promoting Weight Health

By: Ranjay Gulati, Cynthia A. Montgomery, Ashley Whillans, Allison Ciechanover and Emily Grandjean

In December 2023, the 60-year-old weight management industry stalwart WeightWatchers announced the launch of WeightWatchers Clinic, which incorporated GLP-1s , a new class of prescription weight-loss medications, into the company’s portfolio of products and mobile app... View Details

Keywords: Business Strategy; Competitive Strategy; Resource Allocation; Diversification; Leadership; Growth and Development Strategy; Technology Industry; Health Industry; Pharmaceutical Industry; United States; New York (city, NY)

March 2024
Case

Biomanufacturing Decentralization by Stämm

By: Paul A. Gompers, Jenyfeer Martínez Buitrago and Mariana Cal

In Buenos Aires, Argentina, cousins Llamazares and D’Alvia founded Stämm, a startup based on the idea of decentralizing biomanufacturing processes and downsizing biotech facilities. After raising its seed and series A rounds, and while finalizing its series B round in... View Details

Keywords: Business Model; Business Startups; Entrepreneurship; Venture Capital; Selection and Staffing; Technological Innovation; Science-Based Business; Business Strategy; Commercialization; Growth and Development Strategy; Product Launch; Research and Development; Biotechnology Industry; Latin America; South America; Argentina; Buenos Aires

February 2024
Supplement

Seeds of Innovation: GALY's Quest to Cultivate the Future of Agriculture in the Lab

By: George Serafeim

In 2023, Luciano Bueno, CEO and founder of plant cell culture agriculture company GALY, was considering the best path forward for his company as he planned to pitch Series B investors. GALY, founded in 2019, aimed to produce cotton and other crops from cells grown in... View Details

Keywords: Business Model; Green Technology; Goods and Commodities; Growth and Development Strategy; Science-Based Business; Entrepreneurship; Plant-Based Agribusiness; Business Startups; Decisions; Technological Innovation; Production; Entrepreneurial Finance; Agriculture and Agribusiness Industry; Technology Industry; Boston; Sao Paulo

February 2024 (Revised March 2024)
Teaching Note

X: The Foghorn Decision

By: Kyle Myers and Walter Frick

Teaching Note for HBS Case No. 618-060. View Details

January 2024
Case

Fusion Industry Association: Igniting the Future of Clean Energy

By: Joshua Lev Krieger, Jim Matheson, Kyle R. Myers and Henry Tao

Fusion energy is evolving from a scientific idea to a commercial possibility, drawing large investments and regulatory discussions; how should the FIA navigate this evolution?

The Fusion Industry Association (FIA) is at the forefront of transforming fusion... View Details

Keywords: Science-Based Business; Engineering; Venture Capital; Entrepreneurship; Government and Politics; Government Legislation; Industry Clusters; Industry Growth; Industry Structures; Technological Innovation; Energy Industry; United States

December 2023 (Revised March 2024)
Case

Manufacturing Moderna's Future

By: Satish Tadikonda and William Marks

In 2019, Moderna faced long odds of survival having failed to develop a successful clinical program out of the vast platform technology they had built around mRNA. Nearly overnight, the company skyrocketed to success with a vaccine for COVID-19, leading to an extremely... View Details

Keywords: Health Pandemics; Health Testing and Trials; Technological Innovation; Product Development; Production; Science-Based Business; Biotechnology Industry

November 2023 (Revised April 2024)
Case

BiomX: Bringing Phage Back to the Stage

By: Paul A. Gompers, Elie Ofek, Orna Dan and Emilie Billaud

In the spring of 2023, and following the favorable results of a trial involving its phage cocktail for treating lung infections among cystic fibrosis (CF) patients, the leadership of BiomX had several critical issues to wrestle with. First, given its precarious... View Details

Keywords: Working Capital; Financing and Loans; Health Testing and Trials; Product Development; Research and Development; Science-Based Business; Commercialization; Biotechnology Industry; Pharmaceutical Industry

November 2023 (Revised March 2024)
Case

Infarm: Betting the (Indoor) Farm on Food Security

In the summer of 2023, the co-founders of Infarm, a controlled environment agriculture (CEA) company, were contemplating a major pivot going forward. While Infarm had successfully shown it could grow over 75 products—mainly herbs, leafy greens and mushrooms—in modular... View Details

Keywords: Plant-Based Agribusiness; Business Model; Market Entry and Exit; Science-Based Business; Business Strategy; Transition; Agriculture and Agribusiness Industry; Europe; North America; Toronto; Northeastern United States

September 2023 (Revised November 2023)
Case

Seeds of Innovation: GALY's Quest to Cultivate the Future of Agriculture in the Lab

By: George Serafeim and Michael Norris

In 2023, Luciano Bueno, CEO and founder of plant cell culture agriculture company GALY, was considering the best path forward for his company as he planned to pitch Series B investors. GALY, founded in 2019, aimed to produce cotton and other crops from cells grown in... View Details

Keywords: Business Model; Green Technology; Goods and Commodities; Growth and Development Strategy; Science-Based Business; Entrepreneurship; Plant-Based Agribusiness; Business Startups; Decisions; Technological Innovation; Production; Agriculture and Agribusiness Industry; Technology Industry; Boston; Sao Paulo

September 2023 (Revised April 2024)
Case

Atomwise: Strategic Opportunities in AI for Pharma

By: Satish Tadikonda

Abraham Heifets and his co-founder, Izhar Wallach, had founded Atomwise to develop i) an AI engine to transform drug discovery by creating better medicines faster, and ii) a machine learning-based discovery engine that combined the power of convolutional neural... View Details

Keywords: Business Model; Business Startups; AI and Machine Learning; Science-Based Business; Technological Innovation; Biotechnology Industry; Pharmaceutical Industry

September 2023 (Revised March 2024)
Case

ReMo Energy: Sizing Up Investors

By: Jeffrey J. Bussgang and Tom Quinn

In 2023, executives with ReMo Energy (founded 2020) were deciding which size ammonia plant to build as their first project. Their innovative model produced ammonia—useful for making fertilizer and for energy storage—from renewable energy, and they had received funding... View Details

August 2023 (Revised January 2024)
Supplement

Arla Foods: Data-Driven Decarbonization (A)

By: Michael Parzen, Michael W. Toffel, Amram Migdal and Susan Pinckney

Arla implemented a data-based price incentive system to measure, track, and influence climate friendly changes to reduce CO2 emissions across the world’s fourth largest dairy cooperative. View Details

Keywords: Dairy Industry; Business Earnings; Earnings Management; Environmental Accounting; Agribusiness; Animal-Based Agribusiness; Acquisition; Mergers and Acquisitions; Decision Making; Decisions; Voting; Environmental Management; Climate Change; Environmental Regulation; Environmental Sustainability; Green Technology; Pollution; Moral Sensibility; Values and Beliefs; Financial Strategy; Price; Profit; Revenue; Food; Geopolitical Units; Global Strategy; Ownership Type; Cooperative Ownership; Performance Efficiency; Performance Evaluation; Problems and Challenges; Natural Environment; Science-Based Business; Business Strategy; Commercialization; Cooperation; Corporate Strategy; Food and Beverage Industry; Agriculture and Agribusiness Industry; Europe; United Kingdom; European Union; Germany; Denmark; Sweden; Luxembourg; Belgium

August 2023 (Revised March 2024)
Case

Arla Foods: Data-Driven Decarbonization (A)

By: Michael Parzen, Michael W. Toffel, Susan Pinckney and Amram Migdal

The case describes Arla’s history, in particular its climate change mitigation efforts, and how it implemented a price incentive system to motivate individual farms to implement scope 1 greenhouse gas emissions mitigation measures and receive a higher milk price. The... View Details

August 2023 (Revised January 2024)
Supplement

Arla Foods: Data-Driven Decarbonization (B)

By: Michael Parzen, Michael W. Toffel, Susan Pinckney and Amram Migdal

The case describes Arla’s history, in particular its climate change mitigation efforts, and how it implemented a price incentive system to motivate individual farms to implement scope 1 greenhouse gas emissions mitigation measures and receive a higher milk price. The... View Details

January 2023
Case

Natura: Weathering the Pandemic at Brazil's Cosmetic Giant

By: Brian Trelstad, Pedro Levindo and Carla Larangeira

Brazil's Natura, a multi-brand cosmetics group, has taken several measures to safeguard the livelihoods of its thousands of employees and millions of sales representatives during the COVID-19 health and economic crisis. The company has also made strides in its efforts... View Details

2022
Article

Science-based Entrepreneurship in India: A Policy Glass (as yet) Quarter-Full

By: Tarun Khanna

India is celebrated for a resurgence of de novo entrepreneurship in recent decades. Entrants have engaged in creative risk-taking to provide market-based solutions for private or social needs despite not being scions of wealthy industrial or business families. In this... View Details

Keywords: Entrepreneurship; Innovation and Invention; Science; Policy; Investment

November 2021 (Revised May 2022)
Case

QuantumScape's Mission to Revolutionize Energy Storage for a Sustainable Future

By: William A. Sahlman, Allison M. Ciechanover and Jeff Huizinga

QuantumScape CEO Jagdeep Singh juggles the many activities required to lead the next-generation battery pioneer. Founded in 2010, QuantumScape’s mission was to develop new “solid-state” car batteries that would improve upon traditional lithium-ion batteries in key... View Details

Keywords: Batteries; Electric Vehicles; SPACs; Innovation and Management; Technological Innovation; Science-Based Business; Environmental Sustainability; Auto Industry; Energy Industry; California; San Jose

November 2020
Teaching Note

DayTwo: Going to Market with Gut Microbiome

By: Ayelet Israeli

Teaching Note for HBS Case No. 519-010. DayTwo is a young Israeli startup that applies research on the gut microbiome and machine learning algorithms to deliver personalized nutritional recommendations to its users in order to minimize blood sugar spikes after meals.... View Details

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