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      • Faculty Publications  (417)

      Regina E. HerzlingerRemove Regina E. Herzlinger →

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      Faculty

      Regina E. Herzlinger

      Regina E. Herzlinger is the Nancy R. McPherson Professor of Business Administration at the Harvard Business School. She was the first woman to be tenured and chaired at Harvard Business School and serve on many established and start-up corporate health care/medical technology boards. She initiated the courses in non-profit and health care at HBS and was the first faculty member to be selected by...

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      • 10 Dec 2024
      • Interview

      A New Model for Funding Healthcare Innovation

      By: Regina E. Herzlinger and Duke Rohlen
      Ajax Health founder Duke Rohlen (HBS MBA 2001) and HBS Professor Regina Herzlinger join host Brian Kenny to discuss the key success factors for both start-up and established medical technology firms. The case “Ajax Health: A New Model for Medical Technology Innovation”... View Details
      Keywords: Entrepreneurship; Innovation and Invention; Business Model; Private Equity; Health Industry
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      Herzlinger, Regina E., and Duke Rohlen. "A New Model for Funding Healthcare Innovation." Cold Call (podcast), Harvard Business Review Group, December 10, 2024.
      • October 2024
      • Case

      Parexel: Scaling Up and Industry Dynamics

      By: Regina E. Herzlinger and Ben Creo
      Through the lens of biopharmaceutical contract research organization (CRO) PAREXEL, this case traces the evolution of the firm as it reinvents itself in response to the transformation of the CRO sector from a small, secondary cluster of firms into a major player with... View Details
      Keywords: Research; Innovation and Invention; Business Model; Transformation; Globalization; Information Technology; Competitive Advantage; Pharmaceutical Industry
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      Herzlinger, Regina E., and Ben Creo. "Parexel: Scaling Up and Industry Dynamics." Harvard Business School Case 325-046, October 2024.
      • September 2024 (Revised March 2025)
      • Case

      Epic: The Future of Health Information Technology

      By: Regina E. Herzlinger and Brian L. Walker
      How should the founder and leadership team of a health IT company with more than 45 years of market leadership prepare for the future, while navigating founder transitions and industry changes? Founded by Judy Faulkner in the late 1970s, Epic pioneered electronic... View Details
      Keywords: Technological Innovation; Entrepreneurship; Health Care and Treatment; Private Ownership; Customer Focus and Relationships; Health Industry; Electronics Industry
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      Herzlinger, Regina E., and Brian L. Walker. "Epic: The Future of Health Information Technology." Harvard Business School Case 325-028, September 2024. (Revised March 2025.)
      • August 2024
      • Background Note

      The Five Pillars That Drive the Success or Failure of Healthcare and Life Sciences Innovations

      By: Regina E. Herzlinger
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      Herzlinger, Regina E. "The Five Pillars That Drive the Success or Failure of Healthcare and Life Sciences Innovations." Harvard Business School Background Note 325-043, August 2024.
      • August 2024 (Revised August 2024)
      • Background Note

      Note on Adherence in Healthcare

      By: Regina E. Herzlinger, Zachery Page and Ben Creo
      This note provides an overview of adherence in healthcare. It discusses systemwide costs of non-adherence, common barriers to adherence, relevant stakeholders, novel compliance tactics, and the impact on digital therapeutic adoption. It is recommended as a companion to... View Details
      Keywords: Health Care and Treatment; Behavior; Health Industry
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      Herzlinger, Regina E., Zachery Page, and Ben Creo. "Note on Adherence in Healthcare." Harvard Business School Background Note 325-025, August 2024. (Revised August 2024.)
      • August 2024
      • Background Note

      Note on Creating Business Plans for Innovative Health Care Ventures

      By: Regina E. Herzlinger, Ben Creo, Lee Kaplan and Brian L. Walker
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      Herzlinger, Regina E., Ben Creo, Lee Kaplan, and Brian L. Walker. "Note on Creating Business Plans for Innovative Health Care Ventures." Harvard Business School Background Note 325-026, August 2024.
      • July–August 2024
      • Article

      The Middle Path to Innovation

      By: Regina E. Herzlinger, Duke Rohlen, Ben Creo and Will Kynes
      Too many companies are failing to innovate. One reason, say the authors, is the polarized approach companies take to innovation. At one end of the spectrum, corporate R&D efforts tend to focus on product refreshes and incremental line upgrades that generate modest... View Details
      Keywords: Innovation Strategy; Medical Devices and Supplies Industry
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      Herzlinger, Regina E., Duke Rohlen, Ben Creo, and Will Kynes. "The Middle Path to Innovation." Harvard Business Review 102, no. 4 (July–August 2024): 134–145.
      • May 2, 2024
      • Article

      Require Hospitals to Disclose Their Pandemic Plans Now

      By: Regina E. Herzlinger, Richard J. Boxer and Ben Creo
      The COVID-19 pandemic demonstrated that U.S. hospital and health care systems were ill-prepared for the surge of patients who overwhelmed available health care resources. An overlooked resource deserves more attention: the availability of intensive care unit (ICU)... View Details
      Keywords: COVID-19 Pandemic; Crisis Management; Knowledge Sharing; Governance Compliance; Planning; Health Industry; United States
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      Herzlinger, Regina E., Richard J. Boxer, and Ben Creo. "Require Hospitals to Disclose Their Pandemic Plans Now." Health Affairs Forefront (May 2, 2024).
      • 18 Apr 2024
      • Lecture

      Innovation Opportunities Created by COVID-19 Can Help: And How to Make Them Happen

      By: Regina E. Herzlinger
      The crush of patients created by COVID enabled the creation of sites for care outside the traditional hospital, such as retail pharmacies, ambulatory surgery centers, urgent care centers, telemedicine, and wireless sensors. Public policy mirrored these changes by... View Details
      Keywords: Policy; Health Pandemics; Health Care and Treatment; Innovation and Invention; Health Industry; Insurance Industry
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      "Innovation Opportunities Created by COVID-19 Can Help: And How to Make Them Happen." Fortnightly of Chicago, April 18, 2024.
      • January 2024
      • Background Note

      Evaluating Innovations in the Organization of Primary Care: What Type of Innovation Is It and How Well Does It Align with the Six Factors?

      By: Regina E. Herzlinger and James Wallace
      How can we evaluate if innovative health care ventures can do good—benefit society—and do well—become financially viable? This question is the topic of the first module in the Innovating in Health Care course book.

      This note and "Health Stop (A): What Type... View Details
      Keywords: Business Model; Health Care and Treatment; Collaborative Innovation and Invention; Mission and Purpose; Alignment; Health Industry
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      Herzlinger, Regina E., and James Wallace. "Evaluating Innovations in the Organization of Primary Care: What Type of Innovation Is It and How Well Does It Align with the Six Factors?" Harvard Business School Background Note 324-037, January 2024.
      • December 2023
      • Article

      Association of Hospital System Affiliation with COVID-19 Capacity Burden

      By: Zachary Levin, Pinar Karaca-Mandic, Richard J. Boxer and Regina E. Herzlinger
      What is the message? The COVID-19 pandemic exposed the highly variable and uncoordinated responses by hospitals. The authors found that while the non-top ten system affiliated hospitals had a larger COVID-19 share index relative to independent hospitals, top-ten system... View Details
      Keywords: COVID-19 Pandemic; Resource Allocation; Health Pandemics; Demographics; Health Care and Treatment; Health Industry
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      Levin, Zachary, Pinar Karaca-Mandic, Richard J. Boxer, and Regina E. Herzlinger. "Association of Hospital System Affiliation with COVID-19 Capacity Burden." Health Management, Policy and Innovation 8, no. 3 (December 2023).
      • September 2023
      • Supplement

      Fighting the Battle of the Bulge—Evaluating Do Good/Do Well Innovations in Morbid Obesity Treatment

      By: Regina E. Herzlinger
      This PowerPoint accompanies Regina E. Herzlinger's "Fighting the Battle of the Bulge – Evaluating Do Good/Do Well Innovations in Morbid Obesity Treatment" teaching note (HBS Case No.324-013) and is designed for instructors to use in the classroom when teaching this... View Details
      Keywords: Health Care Delivery; Obesity; Weight Loss; Innovation and Invention; Innovation and Management; Health Care and Treatment; Medical Specialties; Health Industry
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      Herzlinger, Regina E. "Fighting the Battle of the Bulge—Evaluating Do Good/Do Well Innovations in Morbid Obesity Treatment." Harvard Business School PowerPoint Supplement 324-016, September 2023.
      • September 2023
      • Teaching Note

      Fighting the Battle of the Bulge—Evaluating Do Good/Do Well Innovations in Morbid Obesity Treatment

      By: Regina E. Herzlinger
      Teaching Note for HBS Case No. 304-009. The case is part of the first module of the Innovating in Health Care course. Its purpose is to demonstrate how to evaluate the “do good” and do well” potential of a health care innovation. View Details
      Keywords: Innovation In Healthcare Delivery; Innovation; Obesity; Digital Health; Weight Loss; Health Care and Treatment; Innovation and Management; Business Model; Medical Specialties; Mission and Purpose; Health Industry
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      Herzlinger, Regina E. "Fighting the Battle of the Bulge—Evaluating Do Good/Do Well Innovations in Morbid Obesity Treatment." Harvard Business School Teaching Note 324-013, September 2023.
      • 3 Jun 2023
      • Talk

      Health Care Innovation Opportunities Created by COVID-19 and How to Make Them Happen

      By: Regina E. Herzlinger
      The crush of patients created by COVID enabled the creation of sites for care outside the traditional hospital, such as retail pharmacies, ambulatory surgery centers, urgent care centers, telemedicine, and wireless sensors. Public policy mirrored these changes by... View Details
      Keywords: Policy; Health Pandemics; Health Care and Treatment; Innovation and Invention; Health Industry; Insurance Industry
      Citation
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      Herzlinger, Regina E. "Health Care Innovation Opportunities Created by COVID-19 and How to Make Them Happen." Harvard Business School Alumni Reunion, Boston, MA, June 3, 2023. (Link to cases described in this talk.)
      • April 2023 (Revised January 2024)
      • Background Note

      Note on Healthcare in Ghana

      By: Regina E. Herzlinger and Ben Creo
      This note provides an overview of the healthcare system in Ghana. It discusses the public and private sector as well as traditional medical practice. It also discusses the country’s pharmaceutical industry. It is recommended as a companion to Professor Regina... View Details
      Keywords: Africa; Pharmaceutical Companies; Pharmacy Benefit Manager; Health Care; Health Care Costs; Health Care Delivery; Health Care Entrepreneurship; Telehealth; Health Equity; Governing Rules, Regulations, and Reforms; Health Care and Treatment; Business and Government Relations; Health Industry; Pharmaceutical Industry; Ghana
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      Herzlinger, Regina E., and Ben Creo. "Note on Healthcare in Ghana." Harvard Business School Background Note 323-112, April 2023. (Revised January 2024.)
      • April 24, 2023
      • Article

      In the COVID Era, Why Corporate Benefits Demand CEO/CFO Leadership

      By: Regina E. Herzlinger
      The expectation that employers provide their employees’ health benefits has been around since World War II. Unfortunately, although today’s employees expect employers to treat them as individuals, ease their experiences, prioritize their wellbeing, and control cost,... View Details
      Keywords: COVID; COVID-19 Pandemic; CEO; Leadership; Health Insurance; Benefits; CFO; Compensation and Benefits
      Citation
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      Herzlinger, Regina E. "In the COVID Era, Why Corporate Benefits Demand CEO/CFO Leadership." CMR Insights (April 24, 2023).
      • March 2023 (Revised March 2025)
      • Case

      Close Concerns: Diabetes Research and Advocacy

      By: Regina Herzlinger and Brian L. Walker
      Diagnosed with diabetes at the age of 18, Kelly Close understood the importance of balancing consistency and iteration. This principle had also informed her professional work, which started with a rapid promotion from financial analyst at Goldman Sachs to an analyst... View Details
      Keywords: Diabetes; Health; Health Care; Health Care And Treatment; Health Care Outcomes; Health Care Industry; Knowledge Dissemination; Outcome or Result; Equality and Inequality; Business Model; Entrepreneurship
      Citation
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      Herzlinger, Regina, and Brian L. Walker. "Close Concerns: Diabetes Research and Advocacy." Harvard Business School Case 323-047, March 2023. (Revised March 2025.)
      • February 2023
      • Article

      Maintaining Health Care Innovations After the Pandemic

      By: Regina E. Herzlinger, Barak D. Richman and Kevin A. Schulman
      The COVID-19 pandemic exposed the worst failings of the health care system, but it also stimulated a flurry of innovations that could lead to a much-improved delivery system. These were innovations that were born out of necessity: telemedicine access and use... View Details
      Keywords: Health Care; Health Care Industry; Health Care Outcomes; Innovation; Innovation In Healthcare Delivery; COVID; COVID-19 Pandemic; Pandemics; Telemedicine; Telehealth; Ambulatory Care; Vaccines; Innovation and Invention; Change; Health Industry
      Citation
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      Herzlinger, Regina E., Barak D. Richman, and Kevin A. Schulman. "Maintaining Health Care Innovations After the Pandemic." e225404. JAMA Health Forum 4, no. 2 (February 2023).
      • January 2023
      • Teaching Note

      Identify the Health Care Venture

      By: Regina E. Herzlinger and James Wallace
      Teaching Note for HBS Exercise No. 323-061. View Details
      Keywords: Health Care; Health Care Delivery; Health Care Financing; Health Care Industry; Health Care Services
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      Herzlinger, Regina E., and James Wallace. "Identify the Health Care Venture." Harvard Business School Teaching Note 323-062, January 2023.
      • January 2023
      • Exercise

      Identify the Health Care Venture

      By: Regina E. Herzlinger and James Wallace
      This case enables rapid learning of the key financial characteristics of many types of health care organizations and to diagnose their financial status. It is a surprisingly fun exercise (see the Teaching Note) accomplished by organizing groups of students that compete... View Details
      Keywords: Health Care; Health Care Spending; Health Care Financing; Health Care Industry; Health Care Operations; Health Care Delivery; Health Care and Treatment; Financial Condition; Health Industry
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      Herzlinger, Regina E., and James Wallace. "Identify the Health Care Venture." Harvard Business School Exercise 323-061, January 2023.
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