Publications

June 2023
Case

Verve Therapeutics: Taking DNA Editing to Heart

By: Shikhar Ghosh and Shweta Bagai

Verve Therapeutics, a public biotech company based in Boston, created a novel approach to addressing cardiovascular disease (CVD) - a leading cause of deaths globally. The company's approach was a single shot treatment to permanently lower cholesterol, thus reducing... View Details

Keywords: AI; Genetic Engineering; Medicine; Health Care and Treatment; Genetics; Innovation Strategy; Business and Stakeholder Relations; Medical Specialties; Innovation and Invention; Entrepreneurship; Biotechnology Industry

September 2019 (Revised August 2020)
Case

Engineering an Inclusive Bioeconomy

By: Tarun Khanna, Raffaella Sadun and Susie L. Ma

In 2019, entrepreneur Juan Carlos Castilla-Rubio was developing a project he hoped could generate and share wealth from the natural resources of the Amazon without destroying those resources. His idea, called Earth Bank of Codes (EBC), would create a library of the... View Details

September 2013 (Revised August 2014)
Case

Claritas Genomics

By: Robert F. Higgins and Matthew Preble

Claritas Genomics was formed in January 2013 when BCH spun out its Genetics Diagnostic Lab into a fully commercial entity. Claritas offered over 100 genomic tests to detect a range of conditions, including autism and intellectual disabilities, and was developing new... View Details

July 2013
Case

Novozymes: Establishing the Cellulosic Ethanol Value Chain

By: Willy Shih and Sen Chai

As the world's largest producer of industrial enzymes, Novozymes had invested heavily for many years to bio-engineer enzymes that could break down cellulose into fermentable sugar. In 2010, the company had launched what it thought would become a breakthrough product... View Details

December 2014 (Revised February 2017)
Case

Simplot Plant Sciences: Designing a Better Potato

By: Jose B. Alvarez and Mary Shelman

Privately held Simplot has developed a new genetically engineered potato that substantially reduces waste and does not turn brown after cutting. Unlike other GMOs, it does not contain foreign genes. The case describes the company's commercialization plans in light of... View Details

Keywords: GMO; Sustainability; Agribusiness; Biotechnology; Food And Environment; Plant-Based Agribusiness; Food; Disruptive Innovation; Technological Innovation; Marketing; Product Positioning; Genetics; Value Creation; Agriculture and Agribusiness Industry; United States

26 Jan 2024
Blog Post

HBS Alumna Fighting Cancer with a Novel Cell Therapy

Ananya Zutshi (MS/MBA 2021) wanted a career in pharmacology biotech, but wasn’t sure if she wanted to be on the management side or scientific side. She studied biomedical engineering as an undergraduate at Duke University, where she... View Details

27 Feb 2024
Blog Post

Fighting Cancer with a Novel Cell Therapy: Ananya Zutshi (MS/MBA '21)

Ananya Zutshi (MS/MBA 2021) wanted a career in pharmacology biotech, but wasn’t sure if she wanted to be on the management side or scientific side. She studied biomedical engineering as an undergraduate at Duke University, where she... View Details

October 2001 (Revised April 2002)
Case

Calgene, Inc.

By: Ray A. Goldberg and John T. Gourville

In 1993, Calgene is on the verge of introducing the world's first genetically engineered plant product--a tomato will taste better and stay fresh longer. At the same time, it is using biotechnology to produce improved plant products for the cottonseed and the... View Details

Keywords: Information Technology; Marketing Strategy; Market Entry and Exit; Product Launch; Innovation Strategy; Social Issues; Production; Problems and Challenges; Biotechnology Industry; Agriculture and Agribusiness Industry

April 1998 (Revised January 2000)
Case

Pioneer Hi-Bred International, Inc.: Supply Management

By: Francis Aguilar, Paul Clark and Xin Xi He

This case depicts the supply-management practices--including planning, production, and distribution--at Pioneer Hi-Bred International, the world's leader in the genetically engineered hybrid crop-seed industry. Set in the context of a supply-management planning... View Details

Keywords: Plant-Based Agribusiness; Production; Distribution; Marketing Strategy; Customer Focus and Relationships; Logistics; Planning; Agriculture and Agribusiness Industry; Biotechnology Industry

Joe Lassiter, Harvard Business School Professor and Faculty Chair of Harvard's Innovation Lab, discusses how businesses can seize on new opportunities and re-invent themselves quickly and effectively at the Better by Design CEO Summit 2015 in Aukland, New Zealand.... View Details

August 2001
Case

Finnigan Corporation

By: Carliss Y. Baldwin and Barbara Feinberg

Finnigan Corp., headquartered in San Jose, CA, was the world's leading producer of mass spectrometers, holding a 45% market share of instruments used for chemical analysis in pharmaceutical product development, environmental testing, genetic testing, and other... View Details

Keywords: Business Exit or Shutdown; Financial Crisis; Machinery and Machining; Technology Industry; San Jose