Publications
Publications
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- All HBS Web
(120,068)
- Faculty Publications (145)
- 2024
- Working Paper
Chimeric Antigen Receptor T-Cell Therapy—Living Drugs: Case Histories of Transformational Advances
By: Amar Bhidé and Srikant M. Datar
In 2017, the US Food and Drug Administration (FDA) approved an immunotherapeutic treatment, called CAR-T therapy, for two kinds of blood cancers—acute leukemia (ALL) and a lymphoma. We describe 1) how CAR-T works, 2) the foundational advances and discoveries, 3) the... View Details
- July 2020
- Case
Applying Data Science and Analytics at P&G
By: Srikant M. Datar, Sarah Mehta and Paul Hamilton
Set in December 2019, this case explores how P&G has applied data science and analytics to cut costs and improve outcomes across its business units. The case provides an overview of P&G’s approach to data management and governance, and reviews the challenges associated... View Details
- 2024
- Working Paper
Cephalosporins—Fighting Hospital Infections: Case Histories of Transformational Advances
By: Amar Bhidé, Srikant Datar and Katherine Stebbins
This case history describes the development of three generations of cephalosporins – antibiotics that have significantly reduced hospital infections. Specifically, we chronicle how: 1) Early (pre-cephalosporin) antibiotics were developed in the first half of the 20th... View Details
- 2024
- Working Paper
Prozac—Controversial Blockbuster: Case Histories of Transformational Advances
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
This case history describes the development of Prozac, a blockbuster drug that transformed
the treatment of depression – and became a cultural phenomenon in the United States. Specifically, we
chronicle the: 1) prior treatments for depression and the research that... View Details
- 2024
- Working Paper
Tamoxifen—Reducing Breast Cancer Risks: Case Histories of Transformational Advances
By: Amar Bhidé, Srikant Datar and Katherine Stebbins
We describe the development of tamoxifen, considered a “gold standard” treatment for
millions of breast cancer patients. Specifically, we describe breast cancer treatments before tamoxifen’s
development; the initial development of tamoxifen from 1960 to 1973;... View Details
- 2024
- Working Paper
Coronary Artery Bypass Grafting—Impossible to Routine: Case Histories of Transformational Advances
By: Amar Bhidé, Srikant M. Datar and Fabio Villa
We describe how Coronary Artery Bypass Grafting (CABG, or more popularly, “bypass”) operations
revolutionized the treatment of coronary disease (that can produce fatal heart attacks and debilitating
angina). Specifically, we chronicle the: 1) development of the... View Details
- 2024
- Working Paper
Antibiotic Treatments for Ulcers--Eradicating H-Pylori Infections: Case Histories of Transformational Advances
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
This case history describes how a chance discovery of bacteria that infect stomach linings completely changed how physicians treat ulcers. Specifically, we chronicle how: 1) two Australian physicians brought the bacterial infection to the world’s attention and... View Details
- 2024
- Working Paper
Computed Tomography (CT)--Beyond Traditional X-Rays: Case Histories of Transformational Advances
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
This case history describes how Computed Tomography (CT) scanners - that combine Xrays
and computers to image soft tissues of the brain and other organs -- have become a widely used
diagnostic tool. Specifically, we chronicle the 1) initial development of CT... View Details
- 2024
- Working Paper
Gastrointestinal Endoscopy--Without Cutting In: Case Histories of Transformational Advances
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
This case history describes how endoscopy transformed the diagnosis of ulcers, cancerous polyps, and other alimentary canal diseases and enabled “minimally invasive” surgeries to treat such diseases. Specifically, we chronicle how: 1) flexible glass fiber endoscopes... View Details
- 2024
- Working Paper
HIV Tests and AIDS Treatments—Containing a Fearsome Pandemic: Case Histories of Transformational Advances
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
This case history describes how a diverse cast of characters, including public health organizations, research laboratories, for-profit healthcare companies, activists, and regulators, rolled back the outbreak of HIV/AIDS in just fifteen years. Moreover, as the case... View Details
- 2024
- Working Paper
Laparoscopy—Minimally Invasive Surgery: Case Histories of Transformational Advances
By: Amar Bhidé, Caitlin N. Bowler and Srikant M. Datar
We describe how operations through laparoscopes – tubular instruments inserted into abdominal cavities – revolutionized gynecological and other surgeries inside the abdomen, such as gall bladder removal. Specifically, we chronicle the 1) foundational contributions of... View Details
- 2025
- Working Paper
Magnetic Resonance Imaging—High Quality and Radiation Free: Case Histories of Transformational Advances
By: Srikant M. Datar, Amar Bhidé and Katherine Stebbins
This case history describes how Magnetic Resource Imaging (MRI) came to complement – and partially replace -- computed tomography (CT) imaging of soft tissue. Specifically, we chronicle 1) the development of foundational techniques and prototypes (through the 1970s);... View Details
- 2025
- Working Paper
Mammography - Early Detection, Precise Diagnoses: Case Histories of Transformational Advances
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
This case history describes how the development of x-ray-based techniques and equipment (“mammography”) led to widespread screening for breast cancer and enabled “minimally invasive” biopsies of breast tumors. Specifically, we chronicle how: 1) new protocols and... View Details
- 2025
- Working Paper
Ultrasound Imaging--Cheap, Versatile, and Safe: Case Histories of Transformational Advances
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
This case history describes how efforts on multiple fronts, including advocacy, training, and technological development, made ultrasound the second most commonly used diagnostic imaging technology (after X-rays). Specifically, we chronicle 1) ultrasound’s development... View Details
- May 2019
- Teaching Note
Data Science at Target
By: Srikant M. Datar and Caitlin N. Bowler
Teaching Note for HBS No. 118-016. View Details
- April 2019
- Teaching Note
The Oakland Athletics: Strategy & Metrics for a Budget
By: Srikant M. Datar and Caitlin N. Bowler
Teaching Note for HBS No. 118-010. View Details
- January 2019
- Case
Philips' Connected Baby Bottle
By: Rajiv Lal, Srikant M. Datar and Caitlin N. Bowler
Keywords: Smart Connected Products
- November 2018
- Case
frog design
By: Srikant M. Datar and Caitlin N. Bowler
The case follows the genesis and development of Palo, a radical urban communications hub designed to replace payphone booths on Manhattan’s city streets, through a joint venture between frog design and a venture-backed firm LQD WiFi. The case explores the complexity of... View Details
- October 2018
- Case
Fundraising at St. Camillus Hospital
By: Srikant M. Datar and Caitlin N. Bowler
St. Camillus is a fictional non-profit hospital in rural Maine facing a serious budget deficit. As Director of Marketing, Victoria Stern is building a team to modernize the hospital fundraising efforts. An interview with a promising candidate, who is also a digital... View Details