Publications

March 2014 (Revised February 2015)
Case

Loki Capital Management

By: Joseph B. Fuller, Shikhar Ghosh and Matthew Preble

In December 2013, Michael Kane was preparing to launch his start-up's first hedge fund. While pleased with the development of the business, he wanted to address a few lingering issues before going any further. He debated whether or not to fire the company's chief... View Details

Keywords: Hedge Fund; Hedge Funds; Equity Split; Fundraising; Investor Clientele; Team Building; Human Resource Management; Human Capital; Human Resources; Equity; Financial Services Industry; United States

January 2023
Case

Cleave Therapeutics: Taking a Risk on Oncology Drug Discovery

By: Regina Herzlinger and Brian Walker

What should a successful executive (HBS Baker Scholar) assess as her next move as the CEO of a firm with a promising and yet uncertain new drug? Amy Burroughs’ mandate to successfully commercialize Cleave Therapeutics’ drug for a cancer with no current successful... View Details

Keywords: Product Development; Leadership; Health Testing and Trials; Research and Development; Risk and Uncertainty; Financial Condition; Partners and Partnerships; Pharmaceutical Industry

January 2005 (Revised March 2006)
Case

Molecular Insight Pharmaceuticals, Inc.

By: Richard G. Hamermesh and Edwin W. Parkinson III

Molecular Insight has developed a novel biopharmaceutical to detect heart attacks. The company's unique approach to intellectual property protection uses the Hatch Waxman Act and the Orphan Drug Act. The company is struggling to raise $7 million in Series B financing.... View Details

Keywords: Intellectual Property; Health Care and Treatment; Pharmaceutical Industry; Health Industry

29 Jan 2019
First Look

New Research and Ideas, January 29, 2019

David Grabowski, and David Cutler Abstract— Medicare’s Hospital Readmissions Reduction Program (HRRP) has been credited with lowering risk-adjusted readmission rates for targeted conditions at general acute care hospitals. However, these... View Details

Keywords: Dina Gerdeman

26 May 2015
First Look

First Look: May 26

http://hrleadsbusiness.org/rise-of-hr-e-book May 2015 JAMA, the Journal of the American Medical Association Medicine's Continuous Improvement Imperative By: Huckman, Robert S., and Ananth Raman Abstract— Maintaining quality and spurring... View Details

Keywords: Sean Silverthorne

26 Mar 2024
Research & Ideas

How Humans Outshine AI in Adapting to Change

continuously understand where they are in the world and what problem they are solving in response to changing circumstances far better than current AI does.” “The current way to achieve this feat with AI is to throw a lot of data at it... View Details

Keywords: by Rachel Layne; Technology; Information Technology

June 2023
Case

Verve Therapeutics: Taking DNA Editing to Heart

By: Shikhar Ghosh and Shweta Bagai

Verve Therapeutics, a public biotech company based in Boston, created a novel approach to addressing cardiovascular disease (CVD) - a leading cause of deaths globally. The company's approach was a single shot treatment to permanently lower cholesterol, thus reducing... View Details

Keywords: AI; Genetic Engineering; Medicine; Health Care and Treatment; Genetics; Innovation Strategy; Business and Stakeholder Relations; Medical Specialties; Innovation and Invention; Entrepreneurship; Biotechnology Industry

19 Mar 2008
Research & Ideas

Finding Success in the Middle of the Market

services. Very careful cost and service tradeoffs are required of companies that continue to dominate the middle ground. Nowhere is controlling midfield more important than politics. With just two mainstream... View Details

Keywords: by John Quelch; Auto; Retail

23 Jan 2024
Research & Ideas

How to Keep Employees Productive: Support Caregivers

furtively wedged between meetings and deadlines. Shifts to remote work and flexible hours during early pandemic lockdowns, for example, made care obligations less secretive. But it might not persist: About 50 percent of employers plan to... View Details

Keywords: by Kara Baskin

09 Feb 2009
Research & Ideas

Uncompromising Leadership in Tough Times

upbeat. Senior management continued to invest in the Dreyer Leadership University [DLU], demonstrating that they cared about employee development. Cronk and others in senior management thought this was an... View Details

Keywords: by Martha Lagace

17 May 2017
Research & Ideas

Minorities Who 'Whiten' Job Resumes Get More Interviews

applying for jobs with employers who said they care about diversity. One black student explained in an interview that with each resume she sent out, she weighed whether to include her involvement in a black student organization: “If the... View Details

Keywords: by Dina Gerdeman

02 Aug 2011
First Look

First Look: August 2

Japanese system, combining its traditional low-cost manufacturing prowess with an ability to bring high-quality, high-margin branded products swiftly to market. Like Samsung, today's emerging giants—Haier in China, Infosys in India, and Koç in Turkey, for instance—face... View Details

Keywords: Sean Silverthorne

October 2022
Case

Afrigen Biologics: Vaccines for the Global South

By: Debora L. Spar and Julia Comeau

The majority of vaccines used on the continent of Africa (99%) are produced offshore. This makes African nations reliant on the West for major health care needs, a problem which was exacerbated by the COVID-19 pandemic. Afrigen Biologics (in partnership with the WHO)... View Details

Keywords: Vaccination; Vaccine; mRNA; COVID; COVID-19; Inequity; Hub-and-spoke; Health Care and Treatment; Health Pandemics; Production; Social Issues; Business and Government Relations; South Africa; Africa

23 Jan 2008
First Look

First Look: January 23, 2008

hourly wage. The entrepreneurial venture's donors were, however, significantly younger, more likely to be from a minority group, and more likely to have died from cancer. For-profit organizations, continuing medical training... View Details

Keywords: Martha Lagace

September–October 2020
Article

The Past, Present, and (Near) Future of Gene Therapy and Gene Editing

By: Julia Pian, Amitabh Chandra and Ariel Dora Stern

Emerging gene therapy and gene-editing technologies will have a growing impact on patient lives and health-care delivery. We analyzed a decade of data on clinical trials and venture capital investments to understand the likely trajectory of genetically focused... View Details

Keywords: Gene Therapy; Gene Editing; Impact; Health Care and Treatment; Technological Innovation; Health Testing and Trials; Venture Capital; Change

Find at Harvard

Read Now

Article

Assessing the Food and Drug Administration's Risk-Based Framework for Software Precertification with Top Health Apps in the United States: Quality Improvement Study

By: Noy Alon, Ariel Dora Stern and John Torous

BACKGROUND: As the development of mobile health apps continues to accelerate, the need to implement a framework that can standardize categorizing these apps to allow for efficient, yet robust regulation grows. However, regulators and researchers are faced with numerous... View Details

Keywords: Mobile Health; Smartphone; Food And Drug Administration; Risk-based Framework; Health Care and Treatment; Mobile and Wireless Technology; Applications and Software; Framework

Read Now

17 Jan 2023
In Practice

8 Trends to Watch in 2023

As 2023 begins, businesses and employees face an uncertain economy and labor market, as the twin dilemmas of inflation and interest rates weigh on forecasts. Harvard Business School faculty share the top trends that they believe will shape the workplace and markets... View Details

Keywords: by Avery Forman

15 Mar 2024
HBS Case

Let's Talk: Why It's Time to Stop Avoiding Taboo Topics at Work

place, discussing one’s next step (or departure) wouldn’t feel abrupt or discriminatory. Health Wing works with a company that saw almost a million dollars in unexpected health care costs last year because the company’s generous health... View Details

Keywords: by Avery Forman

October 2024
Supplement

NOW PT (B)

By: George A Riedel, Allison J. Wigen and Dave Habeeb

Pre-Abstract: Instructors should consider the timing of making videos available to students, as they may reveal key case details. Abstract: In fall 2021, a team of students from the HBS Impact Investing Fund considered Neurologic Optimal Wellness Physical Therapy... View Details

Keywords: Health; Health Care and Treatment; Medical Specialties; Health Industry; United States