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  • September 2017 (Revised July 2023)
  • Case

Adaptive Platform Trials: The Clinical Trial of the Future?

By: Ariel D. Stern and Sarah Mehta
In July 2017, Dr. Brian M. Alexander, president and CEO of the AGILE Research Foundation, was preparing to launch a new type of clinical trial—an adaptive platform trial—to study potential therapies for glioblastoma (GBM), an aggressive form of brain cancer.... View Details
Keywords: Clinical Trials; Cancer; Adaptive Platform Trials; Platform Trials; Adaptive Trials; Glioblastoma; Health; Health Care and Treatment; Health Testing and Trials; Business Strategy; Innovation Strategy; Health Industry; United States
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  • Web

Browse All Articles, Research, & Case Studies - HBS Working Knowledge

while a chatbot may save leaders time, employees might not view the communications as credible. 04 Nov 2024 The Parlor Room Anthony Mayo on What Makes an Effective Leader Chris Linnane Harvard Business School Professor Anthony Mayo joins... View Details
  • 05 Jun 2006
  • Research & Ideas

Using Competition to Reform Healthcare

not performing the surgery at all, and treating the case in a different way. Value may be still greater if preventive care and advice is provided over time so that little or no treatment is needed at all. The relevant business in health... View Details
Keywords: by Michael E. Porter; Health

    Productive Tensions: How Every Leader Can Tackle Innovation’s Toughest Trade-Offs

    How leaders can recast innovation’s toughest trade-offs—efficiency vs. flexibility, consistency vs. change, product vs purpose—as productive tensions.

    Why is leading innovation in today’s dynamic business environment so distressingly... View Details

    • 2021
    • Working Paper

    Kidney Exchange: An Operations Perspective

    By: Itai Ashlagi and Alvin E. Roth
    Many patients in need of a kidney transplant have a willing but incompatible (or poorly matched) living donor. Kidney exchange programs arrange exchanges among such patient-donor pairs, in cycles and chains of exchange, so each patient receives a compatible kidney.... View Details
    Keywords: Kidney Exchange Programs; Health Disorders; Health Care and Treatment; Programs; Design
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    • Program

    Family Office Wealth Management—Virtual

    approaches for managing and preserving family wealth through a live online platform. You may also be interested in the related program: Building a Legacy: Family Office Wealth Management. Key Benefits Successful family offices are adept at managing the tension and... View Details
    • 01 Aug 2006
    • First Look

    First Look: August 1, 2006

    context of race within today's dynamic and diverse organizations. First, we delineate several important reasons why it is critical to discuss mentoring and race. We explore how race has been positioned within the literature to provide a... View Details
    Keywords: Sean Silverthorne
    • Program

    Families in Business

    foundations. All three types of businesses will benefit from this program. Details Address the complex dynamics of a family business Manage expectations for the family's involvement with the business Develop plans for onboarding the... View Details
    • March 2017
    • Case

    PharmAccess and the M-TIBA Platform: Leveraging Digital Technology in the Developing World

    By: Kevin Schulman, Sashidaran Moodley and Anant Vasudevan
    PharmAccess is an Amsterdam-based NGO working to support the development of the private health care market in Africa. This work is critical as over 50% of care is delivered through the private sector, but well-intentioned efforts to address global health through the... View Details
    Keywords: Finance; Entrepreneurship; Health Care and Treatment; Online Technology; Health Industry; Africa; Kenya
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    • Research Summary

    Time Varying Expected Returns, Stochastic Dividend Yields, and Default Probabilities: Linking the Credit Risk and Equity Literature (with George Chacko and Jens Hilscher)

    In standard structural bond pricing models, the firm defaults once the market value of assets has fallen below a threshold. Expected returns, or at least dividend yields, are assumed to be constant, which implies that any asset value movement is permanent and has the... View Details
    • 23 Aug 2004
    • Research & Ideas

    Strategy for Small Fish

    Welcome to the age of business interdependence, say HBS professor Marco Iansiti and collaborator Roy Levien, authors of the new HBSP book The Keystone Advantage: What the New Dynamics of Business Ecosystems Mean for Strategy, Innovation,... View Details
    Keywords: by Marco Iansiti & Roy Levien
    • 16 Jul 2012
    • Working Paper Summaries

    Selection, Reallocation, and Spillover: Identifying the Sources of Gains from Multinational Production

    Keywords: by Laura Alfaro & Maggie X. Chen
    • 04 Jan 2021
    • Working Paper Summaries

    Hospital Allocation and Racial Disparities in Health Care

    Keywords: by Amitabh Chandra, Pragya Kakani, and Adam Sacarny; Health
    • Research Summary

    A major area of Professor Torfason's research is the behavior of individual social network structures. He studies the violation of norms – specifically the use of excessive force in conflict situations – within the empirical context of a large online... View Details

    • 30 Apr 2021
    • Research & Ideas

    Why Anger Makes a Wrongly Accused Person Look Guilty

    researchers were inspired to investigate the link between anger and guilt five years ago after discussing true crime documentaries and the dynamics of the falsely accused being interviewed by police. “As behavioral scientists, we wondered... View Details
    Keywords: by Michael Blanding
    • Program

    Agribusiness Seminar

    deepen their understanding of the food and agriculture landscape, exchange perspectives, strengthen their networks, and cultivate ideas to shape this vital industry. In our upcoming seminar, you will explore current and future industry View Details
    Keywords: Agriculture; Agriculture
    • June 2018
    • Article

    Personal and Social Usage: The Origins of Active Customers and Ways to Keep Them Engaged

    By: Clarence Lee, Elie Ofek and Thomas Steenburgh
    We study how digital service firms can develop an active customer base, focusing on two questions. First, how does the way that customers use the service postadoption to meet their own needs (personal usage) and to interact with one another (social usage) vary across... View Details
    Keywords: Customer Engagement; Adoption Routes; Word-of-Mouth; Digital Marketing; Bayesian Estimation; Customers; Communication; Consumer Behavior; Marketing; Internet and the Web; Analytics and Data Science
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    • Program

    Leading Change and Organizational Renewal

    and managing change, this program prepares you to drive organizational evolution and innovation as the business environment rapidly evolves. You will gain new insight into the strategies used by top global companies to eliminate roadblocks to change—and improve your... View Details
    • 22 Feb 2021
    • Working Paper Summaries

    Private and Social Returns to R&D: Drug Development and Demographics

    Keywords: by Efraim Benmelech, Janice Eberly, Dimitris Papanikolaou, and Joshua Krieger; Pharmaceutical
    • Web

    Students on the Job Market - Doctoral

    numerous potential interventions. To ensure generalization to untested interventions and customers, the IRL model extracts low-dimensional representations of intervention features and customer covariates that are predictive of treatment... View Details