Publications

2024
Working Paper

Chimeric Antigen Receptor T-Cell Therapy—Living Drugs: Case Histories of Transformational Advances

By: Amar Bhidé and Srikant M. Datar

In 2017, the US Food and Drug Administration (FDA) approved an immunotherapeutic treatment, called CAR-T therapy, for two kinds of blood cancers—acute leukemia (ALL) and a lymphoma. We describe 1) how CAR-T works, 2) the foundational advances and discoveries, 3) the... View Details

Keywords: Immunotherapy; Health Care and Treatment; Innovation and Invention; Research and Development; Governing Rules, Regulations, and Reforms

SSRN

1988
Chapter

Originality in Management Accounting Systems: Field Studies of the Processes

By: Robert S. Kaplan

Keywords: Accounting; Innovation and Management

28 Dec 2022
News

US Immigrants Generate 36 percent of Nation’s Innovation, Study Finds

28 Apr 2014
Research & Ideas

Football Stars Debate ‘The Social Capital of the Savvy Athlete’

in front of a standing-room-only audience at the Harvard Innovation Lab at Harvard Business School. Other participants included Arizona Cardinals receiver Larry Fitzgerald, Houston Texans running back Arian... View Details

Keywords: by Carmen Nobel; Sports

01 Dec 2000
News

Everything Old Is New Again: The History of Technological Frontiers

Amazon.com (zealously seeking government-issued patents for e-commerce innovations) and the trio of Netscape, Oracle, and Sun (bolstering the Justice Department's case against Microsoft). Historically, Spar observed, breakthrough View Details

Keywords: Laura Singleton; Microsoft; News, Library, Internet, and Other Services; Information; Broadcasting (except Internet); Information

2004
Book

The Keystone Advantage: What the New Dynamics of Business Ecosystems Mean for Strategy, Innovation, and Sustainability

By: Marco Iansiti and Roy Levien

Keywords: Competitive Advantage; Strategy; Innovation and Invention

Article

Technology, Identity, and Inertia: Through the Lens of 'The Digital Photography Company'

By: Mary Tripsas

Organizations often experience difficulty when pursuing new technology. Large bodies of research have examined the behavioral, social, and cognitive forces that underlie this phenomenon; however, the role of an organization's identity remains relatively unexplored.... View Details

Keywords: Change Management; Disruptive Innovation; Organizational Culture; Behavior; Cognition and Thinking; Identity; Perception; Technology Adoption

September–October 2020
Article

The Past, Present, and (Near) Future of Gene Therapy and Gene Editing

By: Julia Pian, Amitabh Chandra and Ariel Dora Stern

Emerging gene therapy and gene-editing technologies will have a growing impact on patient lives and health-care delivery. We analyzed a decade of data on clinical trials and venture capital investments to understand the likely trajectory of genetically focused... View Details

Keywords: Gene Therapy; Gene Editing; Impact; Health Care and Treatment; Technological Innovation; Health Testing and Trials; Venture Capital; Change

1986
Book

The Art of Innovation: How to Be a Change Master

By: R. M. Kanter

Keywords: Innovation and Invention; Change

20 Oct 2020
Blog Post

Changing the Face of Entrepreneurship and Venture Capital at Harlem Capital

Walking into Harvard Business School as friends, roommates, and colleagues in 2017, Henri Pierre-Jacques (MBA 2019) and Jarrid Tingle (MBA 2019) already knew each other well. What they didn’t know yet was how their angel syndicate, Harlem Capital, would grow, evolve,... View Details

Keywords: Entrepreneurship; Venture Capital / Private Equity

July 2023 (Revised May 2024)
Case

Vytal: Packaging-as-a-Service

By: George Serafeim, Michael W. Toffel, Lena Duchene and Daniela Beyersdorfer

The Germany-based startup Vytal operated the largest digital-native reusable packaging-as-a-service network globally, having raised nearly €15 million, established a large network of restaurant partners, and prevented the use of millions of single-use take-out food... View Details

Educators

Purchase

December 2003 (Revised April 2004)
Case

Blockbuster Inc. & Technological Substitution (D): The Threat of Direct Digital Distribution

Examines the emergence of technologies for delivering video content to consumer homes via direct digital distribution and investigates the strategic options facing video rental giant Blockbuster Inc. as it tries to respond to the new technological substitutes. Examines... View Details

Keywords: Organizational Change and Adaptation; Risk and Uncertainty; Decisions; Technological Innovation; Competition; Change Management; Service Industry; Motion Pictures and Video Industry

Educators

Purchase

2024
Working Paper

Magnetic Resonance Imaging—High Quality and Radiation Free: Case Histories of Transformational Advances

By: Srikant M. Datar, Amar Bhidé and Katherine Stebbins

This case history describes how Magnetic Resource Imaging (MRI) came to complement – and partially replace -- computed tomography (CT) imaging of soft tissue. Specifically, we chronicle 1) the development of foundational techniques and prototypes (through the 1970s);... View Details

Keywords: Health Care and Treatment; Technological Innovation; Innovation Strategy; Technology Adoption; Collaborative Innovation and Invention; Innovation and Invention; Governing Rules, Regulations, and Reforms

SSRN

04 Aug 2023
Blog Post

Four Remarkable Stories of HBS MBA Students Tackling Climate Change

This article was originally published by MBAGRADSCHOOLS, a leading source of information for prospective MBA students. Climate change is not a problem for the future generation, it’s here and now. As the clock keeps ticking, HBS MBA... View Details

2018
Working Paper

Information Provision and Innovation: Natural Experiment of Herbal Patent Prior Art Adoption at the United States and European Patent Offices

By: Prithwiraj Choudhury and Tarun Khanna

We exploit a natural experiment to study how codifying information about prior innovation affects subsequent innovation. A codified database of traditional Indian herbal formulations was adopted by the European Patent Office (EPO) and the U.S. Patent and Trademark... View Details

Keywords: Patents; Plant-Based Agribusiness; Ethnicity; Health Care and Treatment; Pharmaceutical Industry; Agriculture and Agribusiness Industry; China; India

Editorial

Elon Musk's Unusual Compensation Plan Isn't Really About Compensation at All

By: George Serafeim

Earlier this year, Tesla shareholders approved likely the largest compensation package ever awarded to a CEO—for a CEO who clearly doesn’t need the money. Elon Musk is already incredibly rich and also doesn’t seem particularly motivated by further wealth. So why do it?... View Details

Keywords: Tesla; Elon Musk; Innovation; Investor Communication; Investor Relations; Short-termism; Long-termism; Disruption; Executive Compensation; Business and Shareholder Relations; Communication Intention and Meaning; Mission and Purpose

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2008
Working Paper

The Supply Side of Innovation: H-1B Visa Reforms and U.S. Ethnic Invention

By: William R. Kerr and William F. Lincoln

This study evaluates the impact of high-skilled immigrants on US technology formation. Specifically, we use reduced-form specifications that exploit large changes in the H-1B visa program. Fluctuations in H-1B admissions levels significantly influence the rate of... View Details

Keywords: Information Technology; Patents; Ethnicity; Immigration; Innovation and Invention; United States

SSRN

Web

The Idea of Instant Photography - Edwin H. Land & Polaroid | Harvard Business School

developing. EXPLORE MORE OF THE EXHIBIT EXPLORE x HOME EMERGENCE OF A NEW TECHNOLOGY The Invention of the Polarizer A RESEARCH & MANUFACTURING COMPANY Commercialization View Details

March 2016 (Revised April 2017)
Teaching Note

Bridj and the Business of Urban Mobility (A): Introducing a New Model

By: Rosabeth Moss Kanter and Jonathan Cohen

This note is for the purpose of aiding classroom instructors in the use of the Harvard Business School case "Bridj and the Business of Urban Mobility: Introducing a New Model." Instructors may use it to help students understand the challenges that come with disrupting... View Details